确定 microRNAs 在精神疾病中的作用。

Determining the role of microRNAs in psychiatric disorders.

机构信息

1] The Ruhman Family Laboratory for Research on the Neurobiology of Stress, Department of Neurobiology, Weizmann Institute of Science, 76100 Rehovot, Israel. [2] Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, 80804 Munich, Germany.

出版信息

Nat Rev Neurosci. 2015 Apr;16(4):201-12. doi: 10.1038/nrn3879.

DOI:10.1038/nrn3879

PMID:25790865

Abstract

Recent studies have revealed that patients with psychiatric disorders have altered microRNA (miRNA) expression profiles in the circulation and brain. Furthermore, animal studies have shown that manipulating the levels of particular miRNAs in the brain can alter behaviour. Here, we review recent studies in humans, animal models, cellular systems and bioinformatics that have advanced our understanding of the contribution of brain miRNAs to the regulation of behaviour in the context of psychiatric conditions. These studies highlight the potential of miRNA levels to be used in the diagnosis of psychiatric disorders and suggest that brain miRNAs could become novel treatment targets for psychiatric disorders.

摘要

最近的研究表明，患有精神疾病的患者在循环和大脑中存在 miRNA（microRNA）表达谱的改变。此外，动物研究表明，在大脑中操纵特定 miRNA 的水平可以改变行为。在这里，我们回顾了最近在人类、动物模型、细胞系统和生物信息学方面的研究，这些研究增进了我们对脑内 miRNAs 在精神疾病背景下对行为调节的贡献的理解。这些研究强调了 miRNA 水平在精神疾病诊断中的潜在应用，并表明脑内 miRNAs 可能成为精神疾病的新治疗靶点。