Bu Chaozhi, Ren Yongwei, Chen Yuejuan, Zheng Xiaomin
Wuxi Maternity and Child Health Care Hospital, Affiliated Women's Hospital of Jiangnan University, Wuxi, Jiangsu, 214002, China.
Mol Biol Rep. 2025 May 8;52(1):448. doi: 10.1007/s11033-025-10541-z.
Perinatal depression profoundly influences the psychological and physiological well-being of women both during and after pregnancy. This condition encompasses depressive symptoms that manifest as antenatal as well as postnatal depression. Noncoding RNAs (ncRNAs), including microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs), are integral to various cellular processes and have been implicated in the pathophysiology of perinatal depression. These ncRNAs are involved in the regulation of gene expression, maintenance of neuronal function, and modulation of stress responses. Dysregulation of ncRNAs, particularly lncRNAs and miRNAs, has been associated with psychiatric disorders, including perinatal depression. This review explores the classification and functions of ncRNAs, their biological roles, and the evidence linking them to perinatal depression. The investigation of ncRNAs in the context of perinatal depression holds promise for the development of novel therapeutic strategies and the enhancement of health outcomes for both mothers and their children. Future research should prioritize the standardization of methodologies and approaches in this field.
围产期抑郁症对女性孕期及产后的心理和生理健康有着深远影响。这种情况包括表现为产前及产后抑郁的抑郁症状。非编码RNA（ncRNA），包括微小RNA（miRNA）、长链非编码RNA（lncRNA）和环状RNA（circRNA），是各种细胞过程所必需的，并且与围产期抑郁症的病理生理学有关。这些ncRNA参与基因表达调控、神经元功能维持以及应激反应调节。ncRNA的失调，尤其是lncRNA和miRNA的失调，与包括围产期抑郁症在内的精神疾病有关。本综述探讨了ncRNA的分类和功能、它们的生物学作用以及将它们与围产期抑郁症联系起来的证据。在围产期抑郁症背景下对ncRNA的研究有望开发新的治疗策略并改善母亲及其子女的健康结局。未来的研究应优先实现该领域方法和途径的标准化。
