生物技术。基因组工程和生殖系基因修饰的审慎前行之路。
Biotechnology. A prudent path forward for genomic engineering and germline gene modification.
作者信息
Baltimore David, Berg Paul, Botchan Michael, Carroll Dana, Charo R Alta, Church George, Corn Jacob E, Daley George Q, Doudna Jennifer A, Fenner Marsha, Greely Henry T, Jinek Martin, Martin G Steven, Penhoet Edward, Puck Jennifer, Sternberg Samuel H, Weissman Jonathan S, Yamamoto Keith R
机构信息
California Institute of Technology, Mail Code 147-75, Pasadena, CA 91125, USA.
Stanford University School of Medicine, 291 Campus Drive, Stanford, CA 94305, USA.
出版信息
Science. 2015 Apr 3;348(6230):36-8. doi: 10.1126/science.aab1028. Epub 2015 Mar 19.
Abstract
A framework for open discourse on the use of CRISPR-Cas9 technology to manipulate the human genome is urgently needed
摘要
迫切需要一个关于使用CRISPR-Cas9技术操纵人类基因组的公开讨论框架。
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本文引用的文献
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Genome editing. The new frontier of genome engineering with CRISPR-Cas9.基因组编辑。CRISPR-Cas9 技术引领的基因组工程新前沿。
Science. 2014 Nov 28;346(6213):1258096. doi: 10.1126/science.1258096.
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The iCRISPR platform for rapid genome editing in human pluripotent stem cells.用于人类多能干细胞快速基因组编辑的iCRISPR平台。
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Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype.利用 Cas9 在成年小鼠中进行基因组编辑可纠正疾病突变和表型。
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One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering.通过 CRISPR/Cas 介导的基因组工程一步生成携带多个基因突变的小鼠。
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RNA-guided human genome engineering via Cas9.通过 Cas9 进行 RNA 引导的人类基因组工程。
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