Prince G A, Horswood R L, Koenig D W, Chanock R M
J Infect Dis. 1985 Apr;151(4):634-7. doi: 10.1093/infdis/151.4.634.
A recent isolate (9320) of respiratory syncytial virus (RSV) that had been reported to differ from all previous strains was compared with RSV strains isolated over a period of 23 years by using the techniques of in vitro neutralization by specific antiserum and in vivo resistance to infection in cotton rats. The 9320 strain did not appear to be a novel antigenic variant and exhibited greater homology to several prototype strains than did an earlier isolate. The antigenic differences detected by in vitro neutralization disappear when virus strains are compared in vivo. Thus, it appears that concerns that antigenic instability might compromise efforts at RSV prophylaxis are unfounded.
据报道，一种新分离出的呼吸道合胞病毒（RSV）毒株（9320）与之前所有毒株不同。通过使用特异性抗血清体外中和技术以及棉鼠体内抗感染能力，将其与23年间分离出的RSV毒株进行了比较。9320毒株似乎不是一种新的抗原变异株，与几种原型毒株的同源性比早期分离株更高。当在体内比较病毒毒株时，体外中和检测到的抗原差异消失。因此，抗原不稳定可能会影响RSV预防工作的担忧似乎是没有根据的。
