静磁场可短暂改变人类皮质内抑制系统。
Static magnetic field can transiently alter the human intracortical inhibitory system.
作者信息
Nojima Ippei, Koganemaru Satoko, Fukuyama Hidenao, Mima Tatsuya
机构信息
Department of Physical Therapy, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Human Brain Research Center, Kyoto University Graduate School of Medicine, Kyoto, Japan.
出版信息
Clin Neurophysiol. 2015 Dec;126(12):2314-9. doi: 10.1016/j.clinph.2015.01.030. Epub 2015 Feb 19.
OBJECTIVE
Although recent studies have shown the suppressive effects of static magnetic fields (SMFs) on the human primary motor cortex (M1) possibly due to the deformed neural membrane channels, the effect of the clinical MRI scanner bore has not been studied in the same way.
METHODS
We tested whether the MRI scanner itself and compact magnet can alter the M1 function using single- and paired-pulse transcranial magnetic stimulation (TMS).
RESULTS
We found the transient suppression of the corticospinal pathway in both interventions. In addition, the transient enhancement of the short-latency intracortical inhibition (SICI) was observed immediately after compact magnet stimulation.
CONCLUSIONS
The present results suggest that not only the inhomogeneous SMFs induced by a compact magnet but also the homogeneous SMF produced by the MRI scanner bore itself can produce the transient cortical functional change.
SIGNIFICANCE
Static magnetic stimulation can modulate the intracortical inhibitory circuit of M1, which might be useful for clinical purposes.
目的
尽管最近的研究表明静磁场（SMF）可能由于神经膜通道变形而对人类初级运动皮层（M1）具有抑制作用，但尚未以同样的方式研究临床MRI扫描仪孔的影响。
方法
我们使用单脉冲和双脉冲经颅磁刺激（TMS）测试了MRI扫描仪本身和紧凑型磁体是否会改变M1功能。
结果
我们发现在两种干预中皮质脊髓通路均有短暂抑制。此外，在紧凑型磁体刺激后立即观察到短潜伏期皮质内抑制（SICI）的短暂增强。
结论
目前的结果表明，不仅紧凑型磁体诱导的不均匀静磁场，而且MRI扫描仪孔本身产生的均匀静磁场都可以产生短暂的皮层功能变化。
意义
静磁刺激可以调节M1的皮质内抑制回路，这可能对临床目的有用。
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