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重症监护病房中的无家可归患者:一项观察性倾向匹配队列研究。

Homeless Patients in the ICU: An Observational Propensity-Matched Cohort Study.

作者信息

Bigé Naïke, Hejblum Gilles, Baudel Jean-Luc, Carron Annie, Chevalier Sophie, Pichereau Claire, Maury Eric, Guidet Bertrand

机构信息

1Service de Réanimation Médicale, AP-HP, Hôpital Saint-Antoine, Paris, France. 2Faculté de Médecine Pierre et Marie Curie, UPMC Univ Paris 06, Sorbonne Universités, Paris, France. 3U1136, INSERM, Paris, France. 4UMR_S 1136, UPMC Univ Paris 06, Sorbonne Universités, Paris, France. 5Unité de Santé Publique, Hôpital Saint-Antoine, AP-HP, Paris, France. 6Service Social Hospitalier, Hôpital Saint-Antoine, AP-HP, Paris, France. 7Département de l'Information Médicale, Hôpital Saint-Antoine, AP-HP, Paris, France.

出版信息

Crit Care Med. 2015 Jun;43(6):1246-54. doi: 10.1097/CCM.0000000000000944.

Abstract

OBJECTIVE

To describe epidemiology and outcome of critically ill homeless patients, as compared with those of nonhomeless patients.

DESIGN

Homeless and nonhomeless admissions were matched on the basis of a 1:4 ratio, using a propensity score-based procedure involving age, sex, date, and main diagnosis at ICU admission.

SETTING

A 18-bed closed medical ICU of a French tertiary care university hospital.

PATIENTS

All consecutive admissions from July 2000 to December 2012.

INTERVENTIONS

None.

MEASUREMENTS AND MAIN RESULTS

There were 421 homeless and 9,353 nonhomeless admissions. Considering homeless admissions, 50% patients had no health insurance, 56% had no financial resource, 91% were socially isolated, and 69% lived in street. In a multivariable analysis of homeless admissions including age, sex, and Simplified Acute Physiology Score II, living in street was significantly associated with hospital mortality (odds ratio=2.94; 95% CI, 1.30-7.10; p=0.012). As compared with nonhomeless, homeless admissions more frequently concerned men (89% vs 57%; p<0.0001) and younger patients (49 yr [43-57] vs 62 yr [46-76]; p<0.0001), whereas Simplified Acute Physiology Score II (37 [24-50] vs 37 [25-52]; p=0.99) and distribution of the number of organ supports (p=0.49) were similar. ICU mortality concerned 19.1% and 18% of matched homeless and nonhomeless admissions, respectively. The corresponding figures for hospital mortality were 20.8% and 20.6%. In multivariable analysis, homeless status was associated with neither ICU (odds ratio=1.27 [0.92-1.73]; p=0.14) nor hospital mortality (odds ratio=1.07 [0.77-1.49]; p=0.68), while it was independently associated with longer ICU (means ratio=1.16 [1.01-1.34]; p=0.035) and hospital (means ratio=1.30 [1.12-1.49]; p=0.0002) stay of survivors.

CONCLUSIONS

Critically ill homeless patients benefit from the same level of care and have globally the same prognosis than housed patients but experience longer lengths of stay. Most precarious patients living in street have a higher mortality rate. The study perspective is not ICU centered but also concerns the global organization of healthcare since homeless patients are referred by numerous sources and discharged to different wards.

摘要

目的

描述重症无家可归患者的流行病学特征及转归,并与非无家可归患者进行比较。

设计

采用倾向评分法,按照1:4的比例对无家可归和非无家可归的入院患者进行匹配,匹配因素包括年龄、性别、日期以及重症监护病房(ICU)入院时的主要诊断。

地点

法国一所三级护理大学医院的一间设有18张床位的封闭式内科ICU。

患者

2000年7月至2012年12月期间所有连续入院的患者。

干预措施

无。

测量指标及主要结果

共有421例无家可归患者和9353例非无家可归患者入院。在无家可归患者中,50%没有健康保险,56%没有经济来源,91%社会孤立,69%居住在街头。在对无家可归患者入院情况进行的多变量分析中,包括年龄、性别和简化急性生理学评分II,居住在街头与医院死亡率显著相关(比值比=2.94;95%置信区间,1.30 - 7.10;P = 0.012)。与非无家可归患者相比,无家可归患者入院时男性更为常见(89%对57%;P < 0.0001)且患者更年轻(49岁[43 - 57]对62岁[46 - 76];P < 0.0001),而简化急性生理学评分II(37[24 - 50]对37[25 - 52];P = 0.99)以及器官支持数量的分布(P = 0.49)相似。ICU死亡率分别为匹配的无家可归和非无家可归患者入院人数的19.1%和18%。医院死亡率的相应数字分别为20.8%和20.6%。在多变量分析中,无家可归状态与ICU死亡率(比值比=1.27[0.92 - 1.73];P = 0.14)和医院死亡率(比值比=1.07[0.77 - 1.49];P = 0.68)均无关联,而与幸存者在ICU(均值比=1.16[1.01 - 1.34];P = 0.035)和医院(均值比=1.30[1.12 - 1.49];P = 0.0002)的住院时间延长独立相关。

结论

重症无家可归患者与有家可归患者受益于相同水平的医疗护理,总体预后相同,但住院时间更长。大多数生活在街头的最不稳定患者死亡率更高。本研究的视角并非以ICU为中心,而是还涉及医疗保健的整体组织,因为无家可归患者由众多来源转诊并被安置到不同病房。

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