在尼日利亚西南部的马匹中观察到西尼罗河病毒抗体的高血清阳性率。
High seroprevelance of West Nile virus antibodies observed in horses from southwestern Nigeria.
作者信息
Sule Waidi Folorunso, Oluwayelu Daniel Oladimeji, Adedokun Rahamon Akinyele Moshood, Rufai Nurudeen, McCracken Fiona, Mansfield Karen L, Johnson Nicholas
机构信息
1 Department of Biological Sciences, Faculty of Basic and Applied Sciences, Osun State University , Oke-Baale, Osogbo, Osun State, Nigeria .
出版信息
Vector Borne Zoonotic Dis. 2015 Mar;15(3):218-20. doi: 10.1089/vbz.2014.1706.
To investigate exposure of Nigerian horses to West Nile virus (WNV), we determined the seroprevalence rate of anti-WNV antibody in a cohort of 145 horses. Serum samples were collected from three locations in southwestern Nigeria between October, 2011, and July, 2012. The horses were asymptomatic and unvaccinated against WNV at the time of sampling. All sera were tested using a competition enzyme-linked immmunosorbent assay (ELISA) and by an immunoglobulin M (IgM)-specific ELISA. High rates of anti-WNV antibody prevalence were observed in all locations with a mean level of 90.3% (95% confidence interval 84.3-94.6%). None of the horses had detectable anti-WNV IgM. This is the first ELISA-based report of WNV seroprevalence in Nigerian horses and suggests that WNV is enzootic in the study areas, indicating a potential risk of infection in humans and animals.
为调查尼日利亚马匹感染西尼罗河病毒（WNV）的情况，我们测定了145匹马的队列中抗WNV抗体的血清阳性率。2011年10月至2012年7月期间，从尼日利亚西南部的三个地点采集了血清样本。采样时，这些马匹无症状且未接种WNV疫苗。所有血清均使用竞争酶联免疫吸附测定（ELISA）和免疫球蛋白M（IgM）特异性ELISA进行检测。在所有地点均观察到高抗WNV抗体流行率，平均水平为90.3%（95%置信区间84.3-94.6%）。没有一匹马检测到抗WNV IgM。这是第一份基于ELISA的关于尼日利亚马匹WNV血清阳性率的报告，表明WNV在研究区域呈地方流行性，提示人和动物存在潜在感染风险。
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