Kim Hana, Bhattacharya Asmita, Qi Ling
Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, United States.
Graduate Program in Genetics Genomics and Development, Cornell University, Ithaca, NY 14853, United States.
Semin Cancer Biol. 2015 Aug;33:25-33. doi: 10.1016/j.semcancer.2015.02.003. Epub 2015 Mar 18.
Quality control systems in the endoplasmic reticulum (ER) mediated by unfolded protein response (UPR) and endoplasmic reticulum associated degradation (ERAD) ensure cellular function and organismal survival. Recent studies have suggested that ER quality-control systems in cancer cells may serve as a double-edged sword that aids progression as well as prevention of tumor growth in a context-dependent manner. Here we review recent advances in our understanding of the complex relationship between ER proteostasis and cancer pathology, with a focus on the two most conserved ER quality-control mechanisms--the IRE1α-XBP1 pathway of the UPR and SEL1L-HRD1 complex of the ERAD.
由未折叠蛋白反应（UPR）和内质网相关降解（ERAD）介导的内质网（ER）中的质量控制系统确保细胞功能和机体存活。最近的研究表明，癌细胞中的内质网质量控制系统可能是一把双刃剑，在不同背景下既有助于肿瘤进展，也能预防肿瘤生长。在此，我们综述了我们对内质网蛋白质稳态与癌症病理学之间复杂关系的最新认识进展，重点关注两个最保守的内质网质量控制机制——未折叠蛋白反应的IRE1α-XBP1途径和内质网相关降解的SEL1L-HRD1复合体。
