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海洋凝集素及其医学应用。

Marine lectins and their medicinal applications.

作者信息

Cheung Randy Chi Fai, Wong Jack Ho, Pan Wenliang, Chan Yau Sang, Yin Cuiming, Dan Xiuli, Ng Tzi Bun

机构信息

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.

出版信息

Appl Microbiol Biotechnol. 2015 May;99(9):3755-73. doi: 10.1007/s00253-015-6518-0. Epub 2015 Mar 21.

Abstract

Marine organisms have been extensively explored for the last several decades as potential sources of novel biologically active compounds, and extensive research has been conducted on lectins. Lectins derived from marine organisms are structurally diverse and also differ from those identified from terrestrial organisms. Marine lectins appear to be particularly useful in some biological applications. They seem to induce negligible immunogenicity because they have a relatively small size, are more stable due to extensive disulfide bridge formation, and have high specificity for complex glyco-conjugates and carbohydrates instead of simple sugars. It is clear that many of them have not yet been extensively studied when compared with their terrestrial counterparts. Marine lectins can be used to design and develop new potentially useful therapeutic agents. This review encompasses recent research on the isolation and identification of marine lectins with potential value in medicinal applications.

摘要

在过去几十年里,海洋生物作为新型生物活性化合物的潜在来源受到了广泛探索,并且针对凝集素开展了大量研究。源自海洋生物的凝集素在结构上具有多样性,也与从陆地生物中鉴定出的凝集素有所不同。海洋凝集素在某些生物学应用中似乎特别有用。它们似乎引起的免疫原性可忽略不计,因为它们尺寸相对较小,由于广泛形成二硫键而更稳定,并且对复杂糖缀合物和碳水化合物而非单糖具有高特异性。显然,与陆地同类相比,它们中的许多尚未得到广泛研究。海洋凝集素可用于设计和开发新的潜在有用治疗剂。本综述涵盖了近期关于分离和鉴定在医学应用中具有潜在价值的海洋凝集素的研究。

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