McMillen Patrick, Holley Scott A
Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520, United States.
Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520, United States.
Curr Opin Genet Dev. 2015 Jun;32:106-11. doi: 10.1016/j.gde.2015.02.005. Epub 2015 Mar 19.
England's King Richard III, whose skeleton was recently discovered lying ignobly beneath a parking lot, suffered from a lateral curvature of his spinal column called scoliosis. We now know that his scoliosis was not caused by 'imbalanced bodily humors', rather vertebral defects arise from defects in embryonic elongation and segmentation. This review highlights recent advances in our understanding of post-gastrulation biomechanics of the posteriorly advancing tailbud and somite morphogenesis. These processes are beginning to be deciphered from the level of gene networks to a cross-scale physical model incorporating cellular mechanics, the extracellular matrix, and tissue fluidity.
英国国王理查三世的遗骨最近被发现屈辱地躺在一个停车场下面，他患有脊柱侧弯，即脊柱的侧向弯曲。我们现在知道，他的脊柱侧弯并非由“体内体液失衡”引起，而是由于胚胎伸长和分节缺陷导致的椎体缺陷。这篇综述突出了我们在理解原肠胚形成后尾芽向后推进的生物力学和体节形态发生方面的最新进展。这些过程正开始从基因网络层面解读到一个包含细胞力学、细胞外基质和组织流动性的跨尺度物理模型。
