A novel β-lactam derivative, albactam from the flowers of Albizia lebbeck with platelets anti-aggregatory activity in vitro.
作者信息
El-Gamal Ali Ali, Abd-El-Halim Mohamed Farag, Kalil Ashraf Taha, Basudan Omer Ahmed, Al-Rehaily Adnan Jathlan, Ahmad Mohamed Shamim, El-Tahir Kamal Hussin, Al-Massarani Shaza Mohamed, Abdel-Mageed Wael Moustafa
机构信息
Pharmacognosy Department, Faculty of Pharmacy, King Saud University, Riyadh, Saudi Arabia / Pharmacognosy Department, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.
Pharmacognosy Department, Faculty of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
出版信息
Pak J Pharm Sci. 2015 Mar;28(2 Suppl):745-53.
A novel β-lactam derivative, albactam, was isolated from the alcoholic extract of the flowers of Albizia lebbeck. It showed a significant anti-aggregatory activity against adenosine diphosphate and arachidonic acid induced guinea-pigs' platelets aggregation in vitro. Six more known compounds were also isolated and fully characterized by measuring 1D and 2D NMR, two of them are the triterpenes β-amyrin and 11α, 12α-oxidotaraxerol, two ceramide derivatives and two flavonoids, kampferol 3-O-rutinoside and rutin.
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