Yang Chunjuan, An Qi, Xiong Zhili, Song Yang, Yu Kai, Li Famei
School of Pharmacy, Shenyang Pharmaceutical University, 110016 Shenyang, PR China.
Planta Med. 2009 May;75(6):656-9. doi: 10.1055/s-0029-1185330. Epub 2009 Mar 4.
One new triterpenoid saponin and two lupane-derived triterpenes were isolated from Acanthopanax sessiliflorus fruits. The structures of the two new compounds were elucidated as 3- O-[(alpha- L-arabinopyranosyl)-(1 --> 2)]-[ beta- D-glucuronopyranosyl-6- O-methyl ester]-olean-12-ene-28-olic acid (1) and (1 R,11 alpha,22 alpha)-1,4-epoxy-11,22-hydroxy-3,4-secolupane-20(30)-ene-3,28-dioic acid (3) on the basis of spectral analysis, including MS, (1)H-NMR, (13)C-NMR, DEPT, HMBC, HMQC and NOESY. The structure of the other new natural product was elucidated as (1 R,11 alpha)-1,4-epoxy-11-hydroxy-3,4-secolupane-20(30)-ene-3,28-dioic acid (2). All these compounds showed antiplatelet aggregation activity on ADP-induced platelet aggregation.
从无梗五加果实中分离出一种新的三萜皂苷和两种羽扇豆烷型三萜。通过质谱（MS）、氢核磁共振（¹H-NMR）、碳核磁共振（¹³C-NMR）、无畸变极化转移增强法（DEPT）、异核多键相关谱（HMBC）、异核单量子相关谱（HMQC）和核Overhauser效应光谱（NOESY）等光谱分析，确定了这两种新化合物的结构分别为3 - O - [（α - L - 阿拉伯吡喃糖基）-（1→2）]-[β - D - 葡萄糖醛酸吡喃糖基 - 6 - O - 甲酯]-齐墩果 - 12 - 烯 - 28 - 酸（1）和（1R，11α，22α）-1，4 - 环氧 - 11，22 - 二羟基 - 3，4 - 断羽扇豆烷 - 20（30）- 烯 - 3，28 - 二酸（3）。另一种新天然产物的结构确定为（1R，11α）-1，4 - 环氧 - 11 - 羟基 - 3，4 - 断羽扇豆烷 - 20（30）- 烯 - 3，28 - 二酸（2）。所有这些化合物对二磷酸腺苷（ADP）诱导的血小板聚集均表现出抗血小板聚集活性。
