Swamy Bala Yerri, Yun Yeoung-Sang
Division of Semiconductor and Chemical Engineering, Chonbuk National University, Jeonju, Chonbuk 561-756, Republic of Korea.
Division of Semiconductor and Chemical Engineering, Chonbuk National University, Jeonju, Chonbuk 561-756, Republic of Korea.
Int J Biol Macromol. 2015;77:114-9. doi: 10.1016/j.ijbiomac.2015.03.019. Epub 2015 Mar 19.
In the present study, sodium alginate (NaAlg)/sodium carboxymethyl cellulose (NaCMC) blend hydrogel beads were prepared in ferric chloride solution. The developed hydrogel beads exhibited pH sensitive for deliver Metformin hydrochloride (MH). Preparation conditions of the beads (ferric chloride solution) were significantly affected the encapsulation efficiency, swelling and in vitro release profiles of the beads. Swelling studies were accomplished in gastric and intestine stimuli atmosphere at 37°C. The swelling studies reveal that the beads at pH 7.4 showed higher swelling properties compare to pH 1.2. Exterior morphology of beads was analyzed by scanning electron microscope. SEM indicates the surface of the beads is spherical with smooth surface and size of beads drastically reduced with increasing crosslinker concentration. The crosslinking reaction between NaAlg and NaCMC with ferric chloride was confirmed by FTIR analysis. XRD analysis indicates that MH drug molecularly dispersed in the polymer matrix. In vitro release studies of MH loaded beads showed higher release profiles at pH 7.4 compared to pH 1.2. The polymeric matrices followed slightly deviation with Fickian diffusion and fit for experimental co-relation (r(2)) values.
在本研究中，在氯化铁溶液中制备了海藻酸钠（NaAlg）/羧甲基纤维素钠（NaCMC）共混水凝胶珠。所制备的水凝胶珠对盐酸二甲双胍（MH）的递送表现出pH敏感性。珠粒（氯化铁溶液）的制备条件显著影响了珠粒的包封效率、溶胀和体外释放曲线。在37°C的胃和肠刺激环境中进行了溶胀研究。溶胀研究表明，与pH 1.2相比，pH 7.4时的珠粒具有更高的溶胀性能。通过扫描电子显微镜分析了珠粒的外部形态。扫描电子显微镜表明珠粒表面呈球形，表面光滑，且随着交联剂浓度的增加，珠粒尺寸急剧减小。通过傅里叶变换红外光谱（FTIR）分析证实了NaAlg与NaCMC与氯化铁之间的交联反应。X射线衍射（XRD）分析表明MH药物分子分散在聚合物基质中。载有MH的珠粒的体外释放研究表明，与pH 1.2相比，在pH 7.4时具有更高的释放曲线。聚合物基质与菲克扩散略有偏差，符合实验相关（r(2)）值。
