Morozkina Svetlana, Strekalovskaya Ulyana, Vanina Anna, Snetkov Petr, Krasichkov Alexander, Polyakova Victoriya, Uspenskaya Mayya
Chemistry Engineering Centre, ITMO University, Kronverkskiy Prospekt, 49A, 197101 Saint Petersburg, Russia.
Departments of Radio Engineering Systems, Electrotechnical University "LETI", Professor Popova Street 5F, 197022 Saint Petersburg, Russia.
Polymers (Basel). 2022 Sep 1;14(17):3604. doi: 10.3390/polym14173604.
Recently, hydrogels based on natural water-soluble polysaccharides have attracted more and more attention due to their favorable characteristics. The high water-holding capacity, lack of toxicity, and biodegradability of such hydrogels make it possible to develop new materials on their basis for biotechnological, biomedical, pharmacological, and medical purposes. Sodium alginate is a non-toxic natural polysaccharide found in marine algae. It is capable of forming solid gels under the action of polyvalent cations that cross-link polysaccharide chains. Alginate-based products are popular in many industries, including food processing, pharmaceutical, and biomedical applications. Cellulose is the most abundant, renewable, and natural polymer on Earth, and it is used for various industrial and biomedical applications. Carboxymethyl cellulose (CMC) is useful in pharmaceutical, food, and non-food industries such as tablets, ice cream, drinks, toothpaste, and detergents. In this review, various methods for the preparation of the compositions based on sodium alginate and CMC using different crosslinking agents have been collected for the first time. Additionally, the drug release profile from such polymer matrixes was analyzed.
近年来，基于天然水溶性多糖的水凝胶因其优良特性而受到越来越多的关注。此类水凝胶的高持水能力、无毒性和生物可降解性使得在其基础上开发用于生物技术、生物医学、药理学和医学目的的新材料成为可能。海藻酸钠是一种存在于海藻中的无毒天然多糖。它能够在多价阳离子的作用下形成固体凝胶，这些阳离子会交联多糖链。基于海藻酸钠的产品在许多行业都很受欢迎，包括食品加工、制药和生物医学应用。纤维素是地球上最丰富、可再生的天然聚合物，它被用于各种工业和生物医学应用。羧甲基纤维素（CMC）在制药、食品和非食品行业（如片剂、冰淇淋、饮料、牙膏和洗涤剂）中很有用。在这篇综述中，首次收集了使用不同交联剂制备基于海藻酸钠和CMC的组合物的各种方法。此外，还分析了此类聚合物基质的药物释放曲线。
