Hrabia Anna
Department of Animal Physiology and Endocrinology, University of Agriculture in Krakow, Al. Mickiewicza 24/28, 30-059 Krakow, Poland.
Gen Comp Endocrinol. 2015 Sep 1;220:112-8. doi: 10.1016/j.ygcen.2014.12.022. Epub 2015 Mar 18.
The expression and role of growth hormone (GH) in the reproductive system of mammals is rather well established. In birds the limited information thus far available suggests that GH is an endocrine or paracrine/autocrine regulator of ovarian and oviductal functions too. GH and its receptors are expressed in all compartments of the ovary and oviduct and change accordingly to physiological state. The intra-ovarian role of GH likely includes the regulation of steroidogenesis, cell proliferation and apoptosis, the modulation of LH action and the synthesis of IGFs (insulin-like growth factors). In the oviduct, GH is also involved in the regulation of oviduct-specific protein expression. The present study provides a review of current knowledge on the presence and action of GH in the female reproduction, in which it is likely that act in endocrine, autocrine or paracrine mechanisms.
生长激素（GH）在哺乳动物生殖系统中的表达和作用已得到相当充分的确立。在鸟类中，目前有限的信息表明，GH也是卵巢和输卵管功能的内分泌或旁分泌/自分泌调节因子。GH及其受体在卵巢和输卵管的所有区域均有表达，并随生理状态而相应变化。GH在卵巢内的作用可能包括调节类固醇生成、细胞增殖和凋亡、调节促黄体生成素（LH）的作用以及胰岛素样生长因子（IGF）的合成。在输卵管中，GH还参与输卵管特异性蛋白表达的调节.本研究综述了关于GH在雌性生殖中的存在和作用的现有知识，其中GH可能以内分泌、自分泌或旁分泌机制发挥作用。
