Piérard-Franchimont C, Piérard G E, Delvenne P, Hermanns-Lê T
Rev Med Liege. 2014 Oct;69(10):555-8.
The recognition of a complex disorder associating skin psoriasis and its comorbidities has considerably progressed over recent years. Beyond the skin lesions, psoriatic arthritis, the metabolic syndrome, type II diabetes, cardiovascular disease, inflammatory bowel diseases, and some cancers represent a group of chronic systemic disorders. The process is initiated and sustained by an immunological pathway involving Th1, Th17 and Th22 lymphocytes. The recognition of this complex disorder indicates that the clinical impact of psoriasis is not exclusively limited to the skin only.
近年来，对伴有皮肤银屑病及其合并症的复杂疾病的认识有了显著进展。除了皮肤病变外，银屑病关节炎、代谢综合征、II型糖尿病、心血管疾病、炎症性肠病和某些癌症代表了一组慢性全身性疾病。这一过程由涉及Th1、Th17和Th22淋巴细胞的免疫途径启动并持续。对这种复杂疾病的认识表明，银屑病的临床影响不仅限于皮肤。
