Krasil'nikov O V, Ternovskiĭ V I, Sabirov R Z, Tashmukhamedov B A
Biofizika. 1985 Jan-Feb;30(1):79-81.
The influence of some proteolytic enzymes on the properties of the ionic channels induced in the lipid bilayer by three different toxic proteins was studied. It was found that pronase and trypsin did not decrease the conductance of the membranes modified by melittin, alpha-staphylotoxin and latrotoxin and changed its cation-anion selectivity. The dependence of melittin-channels selectivity on the medium pH was investigated. It was suggested that the carbonyl groups of peptide bond take part in defining cation selectivity of the melittin channel.
研究了一些蛋白水解酶对三种不同毒性蛋白在脂质双层中诱导产生的离子通道特性的影响。发现链霉蛋白酶和胰蛋白酶不会降低被蜂毒肽、α-葡萄球菌毒素和黑寡妇蜘蛛毒素修饰的膜的电导，也不会改变其阳离子-阴离子选择性。研究了蜂毒肽通道选择性对介质pH的依赖性。有人提出肽键的羰基参与确定蜂毒肽通道的阳离子选择性。
