Li Meng, Kong Jianxin, Sun Jinlong, Li Xingang
Department of Neurosurgery, Qianfoshan Hospital, Shandong University, Jinan, China.
Department of Neurosurgery, Qilu Hospital, Shandong University, 107 Wenhua West Road, Jinan, Shandong 250012, China.
J Clin Neurosci. 2015 May;22(5):919-21. doi: 10.1016/j.jocn.2014.11.003. Epub 2015 Mar 18.
Intraventricular schwannomas are rare, with only 20 cases reported in the literature to our knowledge, including two cases of schwannomas in the third ventricle. We report a 23-year-old man with a mass in the posterior portion of the third ventricle and obstructive hydrocephalus. The intraventricular mass was clearly visualized and removed by neuroendoscopic surgery, and endoscopic third ventriculostomy was simultaneously performed for the hydrocephalus. Histological and immunohistochemical assays of the surgical sample established a diagnosis of intraventricular schwannoma. The patient had a favourable outcome and no neurological deficits 1 year later. The schwannoma was distant from the choroid plexus, which supports the hypothesis that the schwannoma originated from ectopic neural crest cells that were displaced during embryogenesis.
脑室内神经鞘瘤很罕见,据我们所知,文献中仅报道过20例,其中包括2例第三脑室内神经鞘瘤。我们报告了一名23岁男性,其第三脑室后部有一肿块并伴有梗阻性脑积水。通过神经内镜手术清晰地观察到并切除了脑室内肿块,同时针对脑积水实施了内镜下第三脑室造瘘术。对手术样本进行组织学和免疫组化分析后确诊为脑室内神经鞘瘤。患者预后良好,1年后无神经功能缺损。该神经鞘瘤远离脉络丛,这支持了神经鞘瘤起源于胚胎发育过程中移位的异位神经嵴细胞这一假说。