Siddique Azhar, Saied Sumayya, Mumtaz Majid, Hussain Mirza M, Khwaja Haider A
Unit for Ain Zubaida & Groundwater Research, King Abdulaziz University, Jeddah, Saudi Arabia; Department of Chemistry, University of Karachi, Karachi, Pakistan.
Department of Chemistry, University of Karachi, Karachi, Pakistan.
Ecotoxicol Environ Saf. 2015 Jun;116:129-36. doi: 10.1016/j.ecoenv.2015.03.011. Epub 2015 Mar 20.
Life-time human health risk of cancer attributed to trihalomethanes in drinking water in an urban-industrialized area of Karachi (Pakistan) was conducted through multiple pathways of exposure. The extent of cancer risk was compared with USEPA guidelines. Human health cancer risk for total trihalomethanes (TTHMs) through ingestion and dermal routes were estimated in "acceptable-low risk" (≥1.0E-06; ≤5.10E-05), whereas through inhalation route it was estimated under "acceptable-high risk" (≥5.10E-05; ≤1.0E-04) category. However, at some industrial-urban areas cancer risk for CHCl3 were estimated under "unacceptable risk" (≥1.0E-04) through inhalation route.
通过多种暴露途径，对巴基斯坦卡拉奇一个城市工业化地区饮用水中三卤甲烷所致的终生人类癌症健康风险进行了评估。将癌症风险程度与美国环境保护局（USEPA）的指导方针进行了比较。通过摄入和皮肤途径，总三卤甲烷（TTHMs）的人类健康癌症风险估计处于“可接受低风险”（≥1.0E - 06；≤5.10E - 05）范围内，而通过吸入途径，其估计处于“可接受高风险”（≥5.10E - 05；≤1.0E - 04）类别。然而，在一些工业城市地区，通过吸入途径，三氯甲烷的癌症风险估计处于“不可接受风险”（≥1.0E - 04）范围内。
