Xia Hong-Min, Yang Guo-Qing Ou, Li Chuang-Jun, Yang Jing-Zhi, Ma Jie, Zhang Dan, Li Yan, Li Li, Zhang Dong-Ming
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China; Shandong Academy of Chinese Medicine, Jinan 250014, China.
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Fitoterapia. 2015 Jun;103:83-9. doi: 10.1016/j.fitote.2015.03.016. Epub 2015 Mar 19.
Seven new carbazole alkaloids, clauemarazoles A-G, together with 19 known analogues were isolated from the stems of Clausena emarginata. Their structures were established on the basis of spectroscopic analyses, and the absolute configurations of compounds 1a, 1b, 5a, and 5b were confirmed by their ECD spectroscopy. Compounds 4, 13, 15, and 17 exhibited inhibitory abilities on LPS-induced NO production. Compounds 10-12, 20, 22, and 24 displayed hepatoprotective effects against DL-galactosamine-induced damage in WB-F344 cells.
从凹叶黄皮茎中分离得到7个新的咔唑生物碱，即黄皮咔唑A - G，以及19个已知类似物。通过光谱分析确定了它们的结构，并通过电子圆二色光谱（ECD）确定了化合物1a、1b、5a和5b的绝对构型。化合物4、13、15和17对脂多糖（LPS）诱导的一氧化氮（NO）生成具有抑制能力。化合物10 - 12、20、22和24对DL - 半乳糖胺诱导的WB - F344细胞损伤具有肝保护作用。
