从黄皮茎中提取的生物活性咔唑生物碱。
Bioactive carbazole alkaloids from the stems of Clausena lansium.
作者信息
Du Yi-Qian, Liu Hang, Li Chuang-Jun, Ma Jie, Zhang Dan, Li Li, Sun Hua, Bao Xiu-Qi, Zhang Dong-Ming
机构信息
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China; Department of Pharmacy, Affiliated Drum Tower Hospital of Nanjing University, Zhongshan Road 321, Nanjing 210008, Jiangsu Province, People's Republic of China.
出版信息
Fitoterapia. 2015 Jun;103:122-8. doi: 10.1016/j.fitote.2015.03.018. Epub 2015 Mar 21.
Seven new carbazole alkaloids, claulansines L-R (1-7), and six known analogues (8-13) were isolated from the stems of Clausena lansium. Their structures were elucidated on the basis of spectroscopic analyses, including UV, IR, and NMR experiments (HSQC, HMBC, and NOE experiment). Compound 7 showed moderate anti-inflammatory activities. Compounds 3, 5, 6, 8, and 12 exhibited moderate hepatoprotective activities.
从黄皮树的茎中分离出了7种新的咔唑生物碱，即黄皮树碱L-R（1-7），以及6种已知类似物（8-13）。它们的结构通过光谱分析得以阐明，包括紫外、红外和核磁共振实验（HSQC、HMBC和NOE实验）。化合物7表现出中等程度的抗炎活性。化合物3、5、6、8和12表现出中等程度的肝保护活性。
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