Department of Internal Medicine and AIDS Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea.
Department of Internal Medicine and AIDS Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea.
Clin Chim Acta. 2015 May 20;445:65-9. doi: 10.1016/j.cca.2015.03.015. Epub 2015 Mar 20.
Recent studies have implicated human cytomegalovirus (HCMV) infection as a possible etiological factor in cardiovascular disease. We assessed whether anti-HCMV antibody levels are associated with carotid atherosclerosis and inflammatory cytokine production in elderly Koreans.
Participants (age, ≥65 years) were prospectively enrolled from September 2012 to July 2013 at a 2000-bed university hospital. During the study period, 71 participants (29 males) were prospectively enrolled, and thirty-five (49.3%) of these individuals were in the group designated as high intima-media thickness (IMT).
Multivariate logistic regression analysis revealed three independent risk factors of high IMT: higher levels of anti-HCMV antibody (odds ratio [OR] 1.04, p=0.003), Framingham score (OR 1.14, p=0.018), and levels of IL-1β (OR 2.96, p=0.013). Anti-HCMV antibody levels had a significantly positive correlation with max-IMT (r=0.523, p<0.001), free T4 levels (r=0.315, p=0.021), and Log(TNF-α) (r=0.562, p<0.001) in multivariate correlation analysis.
These findings may provide insight into the role of HCMV in the pathogenesis of atherosclerosis and chronic inflammation in elderly individuals.
最近的研究表明，人类巨细胞病毒（HCMV）感染可能是心血管疾病的一个潜在病因。我们评估了老年韩国人群中抗 HCMV 抗体水平与颈动脉粥样硬化和炎症细胞因子产生之间的关系。
参与者（年龄≥65 岁）于 2012 年 9 月至 2013 年 7 月在一家拥有 2000 张床位的大学医院前瞻性入组。在研究期间，前瞻性入组了 71 名参与者（29 名男性），其中 35 名（49.3%）被指定为内膜中层厚度（IMT）较高的组。
多变量 logistic 回归分析显示，高 IMT 的三个独立危险因素为：抗 HCMV 抗体水平较高（比值比[OR] 1.04，p=0.003）、Framingham 评分（OR 1.14，p=0.018）和 IL-1β 水平（OR 2.96，p=0.013）。抗 HCMV 抗体水平与 max-IMT（r=0.523，p<0.001）、游离 T4 水平（r=0.315，p=0.021）和 Log(TNF-α)（r=0.562，p<0.001）在多变量相关分析中呈显著正相关。
这些发现可能为 HCMV 在老年人群中动脉粥样硬化和慢性炎症发病机制中的作用提供了新的见解。
