Krishan Sukriti, Jansson Patric J, Gutierrez Elaine, Lane Darius J R, Richardson DES, Sahni Sumit
Molecular Pharmacology and Pathology Program, Department of Pathology and Bosch Institute, Blackburn Building (D06), University of Sydney, Sydney, New South Wales, 2006, Australia.
Nagoya J Med Sci. 2015 Feb;77(1-2):1-6.
Autophagy is an important cell survival pathway which is up-regulated under stress conditions. It is a well regulated catabolic process and enables the cell to recycle its constituents and organelles for re-use. Autophagy has been implicated to play an important role in a variety of disorders such as cancer and protein aggregatory neurodegenerative diseases , Alzheimer's disease, Parkinson's disease and Huntington's disease. Iron is a critical metal required for normal cellular functioning. A very tightly regulated balance of iron levels is required for the normal physiological functioning of the cell. Both an excess and deficiency of iron can lead to cellular stress, and thereby, alters the autophagic status within the cell. Thus, it is important to completely understand how iron can affect the autophagic pathway and its potential implications under physiological as well as pathological conditions.
自噬是一条重要的细胞存活途径，在应激条件下会被上调。它是一个受到良好调控的分解代谢过程，使细胞能够回收其成分和细胞器以供再利用。自噬已被认为在多种疾病中起重要作用，如癌症和蛋白质聚集性神经退行性疾病、阿尔茨海默病、帕金森病和亨廷顿病。铁是正常细胞功能所需的关键金属。细胞的正常生理功能需要铁水平非常严格调控的平衡。铁过量和缺乏都会导致细胞应激，从而改变细胞内的自噬状态。因此，全面了解铁如何影响自噬途径及其在生理和病理条件下的潜在影响非常重要。
