Bormann Renata Lilian, da Rocha Eduardo Lima, Kierzenbaum Marcelo Longo, Pedrassa Bruno Cheregati, Torres Lucas Rios, D'Ippolito Giuseppe
MDs, Fellows, Abdominal Imaging, Department of Imaging Diagnosis - Escola Paulista de Medicina da Universidade Federal de São Paulo (EPM-Unifesp), São Paulo, SP, Brazil.
MD, Master, Department of Imaging Diagnosis - Escola Paulista de Medicina da Universidade Federal de São Paulo (EPM-Unifesp), São Paulo, SP, Brazil.
Radiol Bras. 2015 Jan-Feb;48(1):43-51. doi: 10.1590/0100-3984.2013.1794.
Recent studies have demonstrated that the use of paramagnetic hepatobiliary contrast agents in the acquisition of magnetic resonance images remarkably improves the detection and differentiation of focal liver lesions, as compared with extracellular contrast agents. Paramagnetic hepatobiliary contrast agents initially show the perfusion of the lesions, as do extracellular agents, but delayed contrast-enhanced images can demonstrate contrast uptake by functional hepatocytes, providing further information for a better characterization of the lesions. Additionally, this intrinsic characteristic increases the accuracy in the detection of hepatocellular carcinomas and metastases, particularly the small-sized ones. Recently, a hepatobiliary contrast agent called gadolinium ethoxybenzyl dimeglumine, that is simply known as gadoxetic acid, was approved by the National Health Surveillance Agency for use in humans. The authors present a literature review and a practical approach of magnetic resonance imaging utilizing gadoxetic acid as contrast agent, based on patients' images acquired during their initial experiment.
最近的研究表明，与细胞外造影剂相比，在磁共振成像采集过程中使用顺磁性肝胆造影剂可显著提高局灶性肝病变的检测和鉴别能力。顺磁性肝胆造影剂最初显示病变的灌注情况，这与细胞外造影剂相同，但延迟对比增强图像可显示功能性肝细胞摄取造影剂的情况，为更好地表征病变提供更多信息。此外，这种内在特性提高了肝细胞癌和转移瘤，尤其是小尺寸肿瘤的检测准确性。最近，一种名为钆塞酸二钠的肝胆造影剂（简称为钆塞酸）已获国家卫生监督机构批准用于人体。作者基于在最初实验期间获取的患者图像，对使用钆塞酸作为造影剂的磁共振成像进行了文献综述和实际应用方法介绍。
