Laboratory of Genetics, The Salk Institute for Biological Studies La Jolla, CA, USA.
Front Syst Neurosci. 2015 Mar 6;9:34. doi: 10.3389/fnsys.2015.00034. eCollection 2015.
The neurogenesis hypothesis of depression is based on the correlation between the rate of adult hippocampal neurogenesis and the affective status of rodents. However, studies investigating the role of neurogenesis in the causation of mood regulation have reported inconsistent results. Here, we explored whether the affective state can be affected differentially by adult-born neurons with distinctive physiological characteristics at different maturation stages. We revealed that reducing the immature newborn neuron population had no effect on anxiety- or depression-like behaviors in an array of tests; however, it enhanced hyponeophagia in a novelty suppressed feeding test, but only when the novel environment was drastically different from the home cage. We further demonstrated that reducing the immature newborn neuron population led to delayed habituation to a novel environment and impaired contextual learning. Hence, rather than being directly involved in mood regulation, our studies raise the possibility that adult neurogenesis may influence hyponeophagia through its role in mnemonic processing.
抑郁症的神经发生假说基于成年海马神经发生率与啮齿动物情感状态之间的相关性。然而，研究神经发生在调节情绪中的作用的报告结果并不一致。在这里，我们探讨了具有不同生理特征的成年新生神经元在不同成熟阶段是否会对情绪产生不同的影响。我们发现，减少不成熟的新生神经元群体对各种测试中的焦虑或抑郁样行为没有影响；然而，当新环境与家笼有很大不同时，它会增强新奇抑制进食试验中的摄食量减少，但只会增强摄食量减少。我们进一步表明，减少不成熟的新生神经元群体导致对新环境的适应延迟和情景学习受损。因此，我们的研究表明，成年神经发生可能通过其在记忆处理中的作用影响摄食量减少，而不是直接参与情绪调节。
