Minneapolis Medical Research Foundation, Minneapolis, MN, USA.
Department of Neurology, University of Minnesota, Minneapolis, MN, USA.
J Alzheimers Dis. 2018;62(2):833-840. doi: 10.3233/JAD-170767.
The association between longitudinal changes in serum glucose level and longitudinal changes in [18F] Fluorodeoxyglucose-PET (FDG PET) measurements of Alzheimer's disease (AD) risk are unknown.
To investigate whether variation in serum glucose levels across time are associated with changes in FDG PET measurements of cerebral metabolic rate for glucose (rCMRgl) in brain regions preferentially affected by Alzheimer's disease (AD).
Participants are a subset of a prospective cohort study investigating FDG PET, apolipoprotein E (APOE) ɛ4, and risk for AD which includes data from baseline, interim, and follow up visits over 4.4±1.0-years. An automated brain-mapping algorithm was utilized to characterize and compare associations between longitudinal changes in serum glucose levels and longitudinal changes in rCMRgl.
This study included 80 adults aged 61.5±5 years, including 38 carriers and 42 non-carriers of the APOE ɛ4 allele. Longitudinal increases in serum glucose levels were associated with longitudinal CMRgl decline in the vicinity of parietotemporal, precuneus/posterior cingulate, and prefrontal brain regions preferentially affected by AD (p < 0.05, corrected for multiple comparisons). Findings remained significant when controlled for APOE ɛ4 status and baseline and advancing age.
Additional studies are needed to clarify and confirm the relationship between longitudinal changes in peripheral glucose and FDG PET measurements of AD risk. Future findings will set the stage on the use of FDG PET in the evaluation of possible interventions that target risk factors for the development of AD.
血清葡萄糖水平的纵向变化与阿尔茨海默病（AD）风险的[18F]氟脱氧葡萄糖-PET（FDG PET）测量的纵向变化之间的关联尚不清楚。
研究血清葡萄糖水平随时间的变化是否与脑葡萄糖代谢率（rCMRgl）的 FDG PET 测量在受 AD 影响较大的脑区的变化相关。
参与者是一项前瞻性队列研究的一部分，该研究调查了 FDG PET、载脂蛋白 E（APOE）ɛ4 和 AD 风险，其中包括基线、中期和随访的 4.4±1.0 年的数据。使用自动脑映射算法来描述和比较血清葡萄糖水平的纵向变化与 rCMRgl 的纵向变化之间的关联。
本研究包括 80 名年龄为 61.5±5 岁的成年人，其中 38 名携带 APOE ɛ4 等位基因，42 名不携带。血清葡萄糖水平的纵向增加与 AD 受影响较大的顶颞叶、楔前叶/后扣带回和前额叶脑区的纵向 CMRgl 下降相关（p<0.05，经多次比较校正）。当控制 APOE ɛ4 状态和基线及年龄增长时，发现仍然具有统计学意义。
需要进一步的研究来阐明和证实外周葡萄糖的纵向变化与 AD 风险的 FDG PET 测量之间的关系。未来的研究结果将为使用 FDG PET 评估可能针对 AD 发展的风险因素的干预措施奠定基础。
