Sutherland G R, Parslow M I, Baker E
Hum Genet. 1985;69(3):233-7. doi: 10.1007/BF00293031.
Two new classes of common fragile site seen in chromosomes from blood lymphocyte cultures are reported. The first class is induced in bands 1q42 and 19q13 by 5-azacytidine (5-AZA). Maximum induction of these fragile sites occurs when the 5-AZA is added 5-8h prior to harvest. The second class is induced in bands 6q13, 9p21, and 10q21 by bromodeoxyuridine (BrdU). In this instance maximum induction occurred if the BrdU was added 4-6h prior to harvest. The known fragile sites, both rare and common, are summarised.
报告了在血液淋巴细胞培养的染色体中发现的两类新的常见脆性位点。第一类是由5-氮杂胞苷（5-AZA）在1q42和19q13带诱导产生的。当在收获前5-8小时添加5-AZA时，这些脆性位点的诱导达到最大值。第二类是由溴脱氧尿苷（BrdU）在6q13、9p21和10q21带诱导产生的。在这种情况下，如果在收获前4-6小时添加BrdU，则诱导达到最大值。总结了已知的脆性位点，包括罕见的和常见的。
