脊椎动物视网膜中的葡萄糖、乳酸及代谢物穿梭
Glucose, lactate, and shuttling of metabolites in vertebrate retinas.
作者信息
Hurley James B, Lindsay Kenneth J, Du Jianhai
机构信息
Departments of Biochemistry and Ophthalmology, University of Washington, Seattle, Washington.
出版信息
J Neurosci Res. 2015 Jul;93(7):1079-92. doi: 10.1002/jnr.23583. Epub 2015 Mar 20.
Abstract
The vertebrate retina has specific functions and structures that give it a unique set of constraints on the way in which it can produce and use metabolic energy. The retina's response to illumination influences its energy requirements, and the retina's laminated structure influences the extent to which neurons and glia can access metabolic fuels. There are fundamental differences between energy metabolism in retina and that in brain. The retina relies on aerobic glycolysis much more than the brain does, and morphological differences between retina and brain limit the types of metabolic relationships that are possible between neurons and glia. This Mini-Review summarizes the unique metabolic features of the retina with a focus on the role of lactate shuttling.
摘要
脊椎动物的视网膜具有特定的功能和结构，这使其在产生和利用代谢能量的方式上受到一系列独特的限制。视网膜对光照的反应会影响其能量需求，而视网膜的分层结构则会影响神经元和神经胶质细胞获取代谢燃料的程度。视网膜和大脑的能量代谢存在根本差异。视网膜比大脑更依赖有氧糖酵解，并且视网膜和大脑之间的形态差异限制了神经元和神经胶质细胞之间可能存在的代谢关系类型。本综述总结了视网膜独特的代谢特征，重点关注乳酸穿梭的作用。
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