Aubert Agnès, Costalat Robert
Département de Physiologie, Université de Lausanne, Lausanne, Switzerland.
Laboratoire d'Imagerie Fonctionnelle, Université Pierre et Marie Curie-Paris6, INSERM U678, Paris, France.
Glia. 2007 Sep;55(12):1272-1279. doi: 10.1002/glia.20360.
We review the contribution of mathematical modeling of metabolic pathways to the study of the compartmentalization of brain energy metabolism between neurons and glia. We especially focus on the role of lactate in the relationship between glia and neurons and the possible presence of an astrocyte-neuron lactate shuttle (ANLS). We first discuss models of glucose, pyruvate, and lactate kinetics, which are relevant to neuron-glia interactions. We then review models of compartmentalized energy metabolism, which deal with the concepts of 'red' and 'white' stimulations, and the ANLS hypothesis. We next show the contribution of a study of model robustness to the debate about the potential role of lactate in metabolic interactions between glia and neurons. Finally, we discuss the possible implications of modeling for further experimental studies.
我们回顾了代谢途径数学建模对研究神经元和神经胶质细胞之间脑能量代谢区室化的贡献。我们特别关注乳酸在神经胶质细胞与神经元关系中的作用以及星形胶质细胞 - 神经元乳酸穿梭（ANLS）的可能存在。我们首先讨论与神经元 - 神经胶质细胞相互作用相关的葡萄糖、丙酮酸和乳酸动力学模型。然后我们回顾了区室化能量代谢模型，这些模型涉及“红色”和“白色”刺激的概念以及ANLS假说。接下来，我们展示了模型稳健性研究对关于乳酸在神经胶质细胞与神经元代谢相互作用中潜在作用的争论的贡献。最后，我们讨论建模对进一步实验研究的可能影响。
