Department of Cardiology, Gentofte Hospital, University of Copenhagen, Hellerup, DK-2900, Denmark.
Unit of Dermatology and Venereology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Br J Dermatol. 2015 Jul;173(1):159-64. doi: 10.1111/bjd.13781. Epub 2015 Jun 2.
Psoriasis and asthma are disorders driven by inflammation. Psoriasis may carry an increased risk of asthma, but the reverse relationship has not been investigated.
To investigate the risk of psoriasis in subjects with childhood asthma in a nationwide Danish cohort.
Data on all Danish individuals aged 6-14 years at study entry between 1 January 1997 and 31 December 2011 (n = 1,478,110) were linked at an individual level in nationwide registers. Incidence rates per 10,000 person-years were calculated, and incidence rate ratios (IRRs) adjusted for age, sex, concomitant medication and comorbidity were estimated by Poisson regression models.
There were 21,725 cases of childhood asthma and 6586 incident cases of psoriasis. There were 5697 and 889 incident cases of mild and severe psoriasis, respectively. The incidence rates of overall, mild and severe psoriasis were 4.49, 3.88 and 0.61 for the reference population, and 5.95, 5.18 and 0.83 for subjects with childhood asthma, respectively. The IRRs for overall, mild and severe psoriasis were 3.94 [95% confidence interval (CI) 2.16-7.17], 5.03 (95% CI 2.48-10.21) and 2.27 (95% CI 0.61-8.42) for patients with childhood asthma.
Childhood asthma was associated with a significantly increased risk of psoriasis. Further studies are warranted to determine the clinical significance and effects of therapeutic interventions on this association.
银屑病和哮喘都是由炎症驱动的疾病。银屑病可能会增加患哮喘的风险，但尚未研究相反的关系。
在丹麦全国队列中调查儿童哮喘患者发生银屑病的风险。
将所有在 1997 年 1 月 1 日至 2011 年 12 月 31 日期间 6-14 岁时进入研究的丹麦个体的数据（n=1478110）在全国范围内的登记册中进行个体水平链接。计算每 10000 人年的发病率，并通过泊松回归模型估计调整年龄、性别、伴随药物和合并症后的发病率比（IRR）。
共发现 21725 例儿童哮喘和 6586 例银屑病新发病例。分别有 5697 例和 889 例轻度和重度银屑病新发病例。在参考人群中，整体、轻度和重度银屑病的发病率分别为 4.49、3.88 和 0.61，而在儿童哮喘患者中，发病率分别为 5.95、5.18 和 0.83。儿童哮喘患者的整体、轻度和重度银屑病的 IRR 分别为 3.94（95%CI 2.16-7.17）、5.03（95%CI 2.48-10.21）和 2.27（95%CI 0.61-8.42）。
儿童哮喘与银屑病的风险显著增加相关。需要进一步研究以确定这种关联的临床意义和治疗干预措施的影响。
