The Lautenberg Center for Immunology and Cancer Research, IMRIC, Hebrew University-Hadassah Medical School, Jerusalem, Israel.
The Lautenberg Center for Immunology and Cancer Research, IMRIC, Hebrew University-Hadassah Medical School, Jerusalem, Israel.
Trends Immunol. 2015 Apr;36(4):217-28. doi: 10.1016/j.it.2015.02.009. Epub 2015 Mar 21.
Senescent cells, albeit not proliferating, are metabolically and transcriptionally active, thereby capable of affecting their microenvironment, notably via the production of inflammatory mediators. These mediators maintain and propagate the senescence process to neighboring cells, and then recruit immune cells for clearing senescent cells. Among the inflammatory cues are molecules with pronounced tumor-controlling properties, both growth and invasion factors and inhibitory factors, working directly or via recruited immune cells. These senescence-inflammatory effects also prevail within tumors, mediated by the senescent tumor cells and the senescent tumor stroma. Here, we review the course and impact of senescence-associated inflammatory responses in aging and cancer. We propose that controlling senescence-associated inflammation by targeting specific inflammatory mediators may have a beneficial therapeutic effect in treatment of cancer and aging-related diseases.
衰老细胞虽然不再增殖，但具有代谢和转录活性，从而能够影响其微环境，特别是通过产生炎症介质。这些介质维持并促进邻近细胞的衰老过程，然后招募免疫细胞清除衰老细胞。炎症介质中包括具有明显肿瘤控制特性的分子，包括生长和侵袭因子以及抑制因子，它们直接或通过招募的免疫细胞发挥作用。这些衰老-炎症效应也存在于肿瘤中，由衰老的肿瘤细胞和衰老的肿瘤基质介导。在这里，我们综述了衰老相关炎症反应在衰老和癌症中的发生过程和影响。我们提出，通过靶向特定炎症介质来控制衰老相关炎症可能对治疗癌症和与衰老相关的疾病具有有益的治疗效果。
