School of Food Science, Washington State University-University of Idaho, Pullman, WA, USA; Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, TX, USA; Department of Nutrition and Food Science, Texas A&M University, College Station, TX, USA.
Department of Nutrition and Health, Federal University of Vicosa, Viçosa, MG, Brazil.
J Nutr Biochem. 2015 Jun;26(6):633-41. doi: 10.1016/j.jnutbio.2014.12.014. Epub 2015 Feb 26.
Polyphenols from fruits have been implied in the prevention of risk factors for cardiometabolic disorders and cardiovascular disease. The purpose of this study was to investigate if the consumption of peach and plum juice has a protective effect against obesity and metabolic disorders that promote the development of cardiovascular diseases. Obese Zucker and lean rats were fed with peach, plum juice ad libitum or placebo. Body weight gain, biochemical markers and molecular markers for inflammation and cardiovascular disease in heart tissue were quantified. Results show that peach and plum juice consumption protected against a combination of obesity-induced metabolic disorders including hyperglycemia, insulin and leptin resistance, dyslipidemia and low-density lipoprotein oxidation. This was accompanied by a decreased expression of pro-atherogenic and pro-inflammatory biomarkers in plasma and heart tissues including intercellular cell adhesion molecule-1, monocyte chemotactic protein-1, NF-κB and foam cell adherence to aortic arches. In addition, peach and plum juice consumption decreased the levels of angiotensin II in plasma and its receptor Agtr1 in heart tissues, suggesting a role of peach and plum polyphenols as peroxisome proliferator-activated receptor-γ agonists. Furthermore, only plum juice significantly prevented body weight gain and increased the ratio high-density lipoprotein cholesterol/total cholesterol in plasma. This effect is most likely attributed to the plum's higher content of polyphenols (three times that of peach). Altogether, these results imply that cardioprotective effects can be achieved by replacing drinks high in sugar content with fruit juice rich in polyphenols in a diet.
水果中的多酚类化合物被认为可以预防心血管代谢疾病的危险因素和心血管疾病。本研究旨在探究桃和李汁的摄入是否对肥胖和代谢紊乱具有保护作用，而后者会促进心血管疾病的发展。肥胖 Zucker 大鼠和 lean 大鼠自由饮用桃汁、李汁或安慰剂。对体重增加、生化标志物以及心脏组织中炎症和心血管疾病的分子标志物进行了定量分析。结果表明，桃和李汁的摄入可预防肥胖引起的多种代谢紊乱，包括高血糖、胰岛素和瘦素抵抗、血脂异常和低密度脂蛋白氧化。这伴随着血浆和心脏组织中促动脉粥样硬化和促炎生物标志物表达的减少，包括细胞间黏附分子-1、单核细胞趋化蛋白-1、NF-κB 和泡沫细胞对主动脉弓的黏附。此外，桃和李汁的摄入降低了血浆中血管紧张素 II 及其在心脏组织中的受体 Agtr1 的水平，表明桃和李多酚类化合物可能作为过氧化物酶体增殖物激活受体-γ 激动剂发挥作用。此外，只有李汁显著预防了体重增加，并增加了血浆中高密度脂蛋白胆固醇/总胆固醇的比值。这种作用很可能归因于李汁中多酚类化合物的含量更高（是桃汁的三倍）。总之，这些结果表明，在饮食中用富含多酚类化合物的水果汁代替高糖含量的饮料可以达到心脏保护作用。
