Schoenen J, Van Hees J, Gybels J, de Castro Costa M, Vanderhaeghen J J
Life Sci. 1985 Apr 1;36(13):1247-54. doi: 10.1016/0024-3205(85)90269-3.
Various histochemical changes were found in spinal segments L4-L5 of rats with adjuvant arthritis, predominantly 30 days after inoculation. A slight to marked increase of substance P immunoreactivity occurred in laminae I, II and X. FRAP activity was enhanced in lamina II. Serotonin immunoreactivity was heavier in laminae I, VIII and IX in a few animals. The intensity of the histoenzymological reaction for succinic dehydrogenase increased in certain laminae VIII and X neurons. At day 15 of the disease the increase of substance P and FRAP activities was chiefly restricted to the medial portion of the superficial dorsal horn. There was a significant positive correlation between the scratching behaviour of arthritic rats and the substance P immunoreactivity in laminae X and I. If one accepts that scratching is pain-related, the data are consistent with a possible role of substance P in the chronic pain associated with adjuvant arthritis. They leave undetermined the significance of the other histochemical changes.
在佐剂性关节炎大鼠的腰4-腰5脊髓节段发现了多种组织化学变化，主要出现在接种后30天。在I、II和X层中，P物质免疫反应性出现轻微至显著增加。II层的FRAP活性增强。在少数动物中，I、VIII和IX层的5-羟色胺免疫反应性更强。某些VIII和X层神经元中琥珀酸脱氢酶的组织酶学反应强度增加。在疾病第15天，P物质和FRAP活性的增加主要局限于浅表背角内侧部分。关节炎大鼠的搔抓行为与X层和I层中P物质免疫反应性之间存在显著正相关。如果认为搔抓与疼痛相关，那么这些数据与P物质在佐剂性关节炎相关慢性疼痛中可能发挥的作用是一致的。它们未确定其他组织化学变化的意义。
