超声回声强度可预测囊性纤维化患者的严重胰腺病变。
Ultrasound echo-intensity predicts severe pancreatic affection in cystic fibrosis patients.
作者信息
Engjom Trond, Erchinger Friedemann, Lærum Birger N, Tjora Erling, Gilja Odd H, Dimcevski Georg
机构信息
Department of Clinical Medicine, University of Bergen, Bergen, Norway; Department of Medicine, Haukeland University Hospital, Bergen, Norway.
Department of Clinical Medicine, University of Bergen, Bergen, Norway; Department of Medicine, Voss Hospital, Voss, Norway.
出版信息
PLoS One. 2015 Mar 24;10(3):e0121121. doi: 10.1371/journal.pone.0121121. eCollection 2015.
BACKGROUND
Pancreatic destruction affects the majority of patients with cystic fibrosis. We aimed to relate ultrasound findings to exocrine pancreatic function and cystic fibrosis genotype.
METHODS
Patients with cystic fibrosis and a matched group of healthy controls were included. We performed transabdominal ultrasound, and recorded echo intensities of the pancreas and parenchymal characteristics according to endoscopic ultrasound based Rosemont criteria.
RESULTS
We included 39 patients and 29 healthy controls. The cystic fibrosis patients were grouped according to exocrine pancreatic function; Cystic fibrosis, insufficient (n = 20) and sufficient (n = 19). Echo intensity measures and visual score demonstrated hyper-echogenicity in the pancreas insufficient group compared to the pancreas sufficient groups (p<0.001). Ductal and parenchymal changes were not prevalent in any of the groups.
CONCLUSION
The hyper-echoic pancreas was the most frequent ultrasonographic finding in exocrine pancreas insufficient cystic fibrosis patients. Pancreatic echo levels correlated to pancreatic phenotype.
背景
胰腺破坏影响大多数囊性纤维化患者。我们旨在将超声检查结果与胰腺外分泌功能及囊性纤维化基因型相关联。
方法
纳入囊性纤维化患者及一组匹配的健康对照。我们进行了经腹超声检查，并根据基于内镜超声的罗斯蒙特标准记录胰腺的回声强度及实质特征。
结果
我们纳入了39例患者和29例健康对照。囊性纤维化患者根据胰腺外分泌功能分组；胰腺功能不全（n = 20）和胰腺功能充足（n = 19）。与胰腺功能充足组相比，胰腺功能不全组的回声强度测量及视觉评分显示胰腺呈高回声（p<0.001）。导管和实质改变在任何一组中均不常见。
结论
胰腺高回声是胰腺外分泌功能不全的囊性纤维化患者最常见的超声检查发现。胰腺回声水平与胰腺表型相关。
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