Higa S, Markey S P
Anal Biochem. 1985 Jan;144(1):86-93. doi: 10.1016/0003-2697(85)90087-9.
A putative pineal metabolite, 5-methoxyindole-3-acetic acid, was quantified in human urine by a gas chromatographic-mass spectrometric method. Excretion of 4.77 +/- 2.25 microgram/day (mean +/- SD) was consistent from each of three normal subjects over 2-4 weeks. Excretion did not vary with regard to menstrual cycle. The daily pattern of excretion bore no relationship to that of 6-hydroxymelatonin, the major metabolite of melatonin, indicating that the major portion of urinary 5-methoxyindole-3-acetic acid does not derive from melatonin.
采用气相色谱-质谱法对人尿中一种假定的松果体代谢物5-甲氧基吲哚-3-乙酸进行了定量分析。三名正常受试者在2至4周内，每人每天的排泄量为4.77±2.25微克（平均值±标准差），排泄情况较为稳定。排泄量在月经周期方面没有变化。排泄的每日模式与褪黑素的主要代谢物6-羟基褪黑素的模式无关，这表明尿中5-甲氧基吲哚-3-乙酸的主要部分并非来自褪黑素。
