Achira Labs Pvt. Ltd., 57, 1st Main Road, JP Nagar Phase 3, Bangalore 560078, India.
Lab Chip. 2015 May 7;15(9):2064-72. doi: 10.1039/c5lc00041f.
We present textile weaving as a new technique for the manufacture of miniature electrochemical sensors with significant advantages over current fabrication techniques. Biocompatible silk yarn is used as the material for fabrication instead of plastics and ceramics used in commercial sensors. Silk yarns are coated with conducting inks and reagents before being handloom-woven as electrodes into patches of fabric to create arrays of sensors, which are then laminated, cut and packaged into individual sensors. Unlike the conventionally used screen-printing, which results in wastage of reagents, yarn coating uses only as much reagent and ink as required. Hydrophilic and hydrophobic yarns are used for patterning so that sample flow is restricted to a small area of the sensor. This simple fluidic control is achieved with readily available materials. We have fabricated and validated individual sensors for glucose and hemoglobin and a multiplexed sensor, which can detect both analytes. Chronoamperometry and differential pulse voltammetry (DPV) were used to detect glucose and hemoglobin, respectively. Industrial quantities of these sensors can be fabricated at distributed locations in the developing world using existing skills and manufacturing facilities. We believe such sensors could find applications in the emerging area of wearable sensors for chemical testing.
我们提出了一种将纺织品编织技术应用于制造微型电化学传感器的新方法，该方法相对于当前的制造技术具有显著优势。生物相容性的丝纱被用作制造材料，而不是商业传感器中使用的塑料和陶瓷。在将导电油墨和试剂手动编织成织物补丁以制造传感器阵列之前，丝纱先进行涂层处理，然后将其层压、切割并包装成单个传感器。与传统的丝网印刷不同，丝网印刷会导致试剂浪费，而纱线涂层只使用所需的试剂和油墨。亲水性和疏水性纱线用于图案化，以使样品流仅限于传感器的小区域。这种简单的流体控制可以通过现成的材料来实现。我们已经制造和验证了用于葡萄糖和血红蛋白的单个传感器以及一个可以同时检测两种分析物的多路复用传感器。计时安培法和差分脉冲伏安法（DPV）分别用于检测葡萄糖和血红蛋白。在发展中国家的各个地方，可以使用现有的技能和制造设备来大量生产这些传感器。我们相信，这些传感器可以在新兴的可穿戴化学测试传感器领域得到应用。
