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海分枝杆菌感染:病例报告。

Mycobacterium marinum infection: a case report.

机构信息

Instituto Lauro de Souza Lima, Rodovia Comandante João Ribeiro de Barros, km 225/226, Bauru, SP CEP 17.034-971 Brazil.

Department of Public Health, Botucatu Medical School, UNESP - Univ Estadual Paulista, Av. Prof. Montenegro Bairro: Distrito de Rubião Junior, s/n - 18618970 Botucatu, SP Brazil.

出版信息

J Venom Anim Toxins Incl Trop Dis. 2015 Mar 20;21:7. doi: 10.1186/s40409-015-0008-9. eCollection 2015.

Abstract

The infection by Mycobacterium marinum in humans is relatively uncommon. When it occurs, it mainly affects the skin, usually with a chronic, indolent and benign evolution. The diagnosis requires a high index of suspicion, and a significant delay may be observed between the first symptoms to the final diagnosis. This present case reports a M. marinum infection in an immunocompetent patient that had a chronic undiagnosed injury on the dominant hand for at least five years. The patient had several medical consultations, without proper suspicion, hampering adequate diagnostic investigation. Histopathology detected tuberculoid granulomas, but showed no acid-fast bacilli. The culture in appropriate medium and the polymerase chain reaction-restriction enzyme analysis (PRA)-hsp65 confirmed the diagnosis. Treatment with clarithromycin (1 g/day) for three months was effective. Although uncommon, this infection is a contact zoonosis. Therefore, it is important for clinicians to be aware of this diagnosis and properly guide preventable measures to professionals that are in risk group.

摘要

人类感染海洋分枝杆菌相对少见。当发生感染时,主要影响皮肤,通常呈慢性、惰性和良性演变。诊断需要高度怀疑,从最初症状到最终诊断可能会有明显的延迟。本病例报告了一例免疫功能正常的患者,其优势手上有一处慢性未确诊的损伤,至少已有五年。患者曾多次就医,但未引起足够的怀疑,阻碍了适当的诊断性检查。组织病理学检查发现结核样肉芽肿,但未发现抗酸杆菌。适当培养基的培养和聚合酶链反应-限制性内切酶分析(PRA)-hsp65 证实了诊断。采用克拉霉素(1g/天)治疗三个月有效。尽管这种感染不常见,但它是一种接触性动物传染病。因此,临床医生了解这一诊断并为处于危险人群的专业人员提供可预防措施非常重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1131/4372314/fe8d1866e01c/40409_2015_8_Fig1_HTML.jpg

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