Opperer Mathias, Gerner Peter, Memtsoudis Stavros G
Department of Anesthesiology, Hospital for Special Surgery, 535 East 70th Street, New York, NY 10021, USA.
Pain Manag. 2015;5(2):117-28. doi: 10.2217/pmt.15.2.
A multitude of studies have focused on individual additives to local anesthetics and their effect on quality, onset, duration, spread and selectivity, as well as the potential toxic effects of their use. This review aims to give a broad overview of the current evidence in this developing field, based on beneficial and adverse effects of these drugs. We discuss the limitations of the available data and hope to convey implications and future perspectives for clinicians and researchers alike.
众多研究聚焦于局部麻醉药中的个别添加剂及其对质量、起效时间、持续时间、扩散和选择性的影响，以及使用这些添加剂的潜在毒性作用。本综述旨在基于这些药物的有益和不良影响，对这一发展中领域的现有证据进行全面概述。我们讨论了现有数据的局限性，并希望为临床医生和研究人员传达其意义及未来前景。
