卵巢或乳腺腺癌患者淋巴细胞中银染核仁组织区的多态性
Polymorphism of Ag-stained nucleolus organizer regions in lymphocytes of patients with ovarian or breast adenocarcinoma.
作者信息
Kivi S, Mikelsaar A V
出版信息
Hum Genet. 1985;69(4):350-2. doi: 10.1007/BF00291655.
The Ag-stainability of nucleolus organizer regions (NORs) in the acrocentric chromosomes identified by Q-banding was studied in 45 female patients with adenocarcinoma of the ovary or breast and in 45 healthy females. Significantly higher frequencies of Ag(+)NORs per individual (8.8 and 8.3; P less than 0.05), in the G group chromosomes (3.6 and 3.2; P less than 0.05), and in chromosome 21 (1.9 and 1.7; P less than 0.02) were found in patients, compared with controls. Despite the lack of significant differences in NORs between the groups of patients with ovarian and breast adenocarcinoma, the main difference between the patients and controls was due to the patients with adenocarcinoma of the ovary, where a significantly higher frequency of Ag(+)NORs was found in chromosomes 21 (P less than 0.01) and 13 (P less than 0.05).
在45例卵巢癌或乳腺癌女性患者及45例健康女性中，研究了经Q带鉴定的近端着丝粒染色体核仁组织区（NORs）的银染性。与对照组相比，患者个体中Ag(+)NORs的频率显著更高（分别为8.8和8.3；P<0.05），在G组染色体中（分别为3.6和3.2；P<0.05），以及在21号染色体中（分别为1.9和1.7；P<0.02）。尽管卵巢癌和乳腺癌患者组之间NORs无显著差异，但患者与对照组的主要差异在于卵巢癌患者，其21号染色体（P<0.01）和13号染色体（P<0.05）中Ag(+)NORs的频率显著更高。
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