人类近端着丝粒染色体上银染核仁组织区的频率
Frequency of Ag-stained nucleolus organizer regions in the acrocentric chromosomes of man.
作者信息
Mikelsaar A V, Schmid M, Krone W, Schwarzacher H G, Schnedl W
出版信息
Hum Genet. 1977 Jun 10;37(1):73-7. doi: 10.1007/BF00293774.
The Ag-stainability of the nucleolus organizer region (NOR) was studied in the acrocentric chromosomes identified by Q-banding of cultured lymphocytes in 51 karyotypically normal persons (31 males and 20 females). A consistent pattern of Ag-positive NORs was found in each individual. Ninety percent of individuals have a model number of 8--10 Ag-positive NORs per cell. The frequency of Ag-positive NORs is similar in all five acrocentrics. A statistically nonsignificant lower frequency is found in chromosome 22. Ag-negative NORs on both homologues were found in four cases. The observed frequency distribution of individuals with homozygous NOR-positive, heterozygous, and homozygous negative acrocentric chromosomes was in accordance with the Hardy-Weinberg law in all five pairs of the acrocentric chromosomes as well as in total. No sex difference was observed on our material.
在51名核型正常的人（31名男性和20名女性）中，通过对培养淋巴细胞进行Q带分析鉴定出近端着丝粒染色体，研究了核仁组织区（NOR）的银染性。在每个个体中都发现了一致的Ag阳性NOR模式。90%的个体每个细胞中Ag阳性NOR的数量为8 - 10个。在所有五条近端着丝粒染色体中，Ag阳性NOR的频率相似。在22号染色体上发现频率略低，但无统计学意义。在4例中发现同源染色体上均为Ag阴性NOR。在所有五对近端着丝粒染色体以及总体中，观察到的纯合NOR阳性、杂合和纯合阴性近端着丝粒染色体个体的频率分布均符合哈迪-温伯格定律。在我们的材料中未观察到性别差异。
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