人类近端着丝粒染色体核仁组织区（NORs）银染的群体多态性。

Populational polymorphisms in silver staining of nucleolus organizer regions (NORs) in human acrocentric chromosomes.

作者信息

Mikelsaar A V, Ilus T

出版信息

Hum Genet. 1979 Oct 2;51(3):281-5. doi: 10.1007/BF00283395.

Abstract

The Ag stainability of the nucleolus organizer region (NOR) was studied in the acrocentric chromosomes identified by Q banding of cultured lymphocytes in 41 karyotypically normal persons (33 males and 8 females) originating from southeast Estonia. The data obtained are compared with those established earlier for a combined Vienna-Ulm population of 51 karyotypically normal persons (see Mikelsaar et al., 1977a). Significant differences between the two populations in the frequency and patterns of Ag-positive NORs were found. The following findings were most striking: the frequency of Ag-positive NORs in chromosome 14 and in the totals was significantly lower in the Estonian population than in the Vienna-Ulm population (P less than 0.01). The average modal number of Ag-positive NORs per individual was 7.8 in the Estonian population and 8.7 in the Vienna-Ulm sample (P less than 0.01). If the data of the two populations were combined the frequency of positive NORs was significantly (P less than 0.05) lower in chromosome 22 than in 13, 15, and 21, but not 14.

摘要

对爱沙尼亚东南部41名核型正常个体（33名男性和8名女性）培养淋巴细胞进行Q带分析鉴定出的近端着丝粒染色体中的核仁组织区（NOR）的银染性进行了研究。将获得的数据与之前为51名核型正常个体的维也纳-乌尔姆混合人群建立的数据进行了比较（见Mikelsaar等人，1977a）。发现这两个人群在Ag阳性NORs的频率和模式上存在显著差异。以下发现最为显著：爱沙尼亚人群中14号染色体和总数中Ag阳性NORs的频率显著低于维也纳-乌尔姆人群（P<0.01）。爱沙尼亚人群中每个个体Ag阳性NORs的平均众数为7.8，维也纳-乌尔姆样本中为8.7（P<0.01）。如果将两个人群的数据合并，22号染色体中阳性NORs的频率显著低于13、15和21号染色体（P<0.05），但不低于14号染色体。