Liu Hong, Zhao Min, Yang Shen, Gong Dian-Rong, Chen De-Zhe, Du De-Yong
Department of Neurology, Liaocheng Hospital, Liaocheng, 252000, China.
J Nat Med. 2015 Jul;69(3):358-65. doi: 10.1007/s11418-015-0901-0. Epub 2015 Mar 26.
This study investigated the neuroprotective effects of (2R,3S)-pinobanksin-3-cinnamate (PNC) in rats with occlusion-damaged bilateral common carotid arteries. Administration with PNC (5 and 10 mg/kg/day) for 5 weeks significantly improved the behavioral performance of rats with vascular dementia, as showed in the Morris water maze test by shortening the escape latency and latency of crossing, completing more platform crossings, as well as spending more time in the target zone. Further evaluations found that PNC could markedly decrease malondialdehyde levels, enhance superoxide dismutase activity and glutathione levels, and decrease the release of cytochrome c as well as the activities of caspases. Moreover, PNC increased Nrf2 and anti-apoptotic bcl-2 protein expression, while Nox1 and pro-apopotic bax protein expression was decreased. PNC may exert its neuroprotective effects through counteracting oxidative stress and has the potential to treat vascular dementia.
本研究调查了(2R,3S)-松属素-3-肉桂酸酯（PNC）对双侧颈总动脉闭塞损伤大鼠的神经保护作用。连续5周给予PNC（5和10毫克/千克/天）可显著改善血管性痴呆大鼠的行为表现，如在莫里斯水迷宫试验中缩短逃避潜伏期和穿越潜伏期、增加穿越平台次数以及在目标区域停留更多时间所示。进一步评估发现，PNC可显著降低丙二醛水平，增强超氧化物歧化酶活性和谷胱甘肽水平，减少细胞色素c的释放以及半胱天冬酶的活性。此外，PNC增加了Nrf2和抗凋亡蛋白bcl-2的表达，同时降低了Nox1和促凋亡蛋白bax的表达。PNC可能通过对抗氧化应激发挥其神经保护作用，具有治疗血管性痴呆的潜力。
