Rocchi Lorenzo, Niccolini Flavia, Politis Marios
Neurodegeneration Imaging Group, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London, SE5 8AF, UK.
J Neurol. 2015 Sep;262(9):2182-94. doi: 10.1007/s00415-015-7711-x. Epub 2015 Mar 26.
Over the recent years, the application of neuroimaging techniques such as magnetic resonance imaging (MRI) and positron emission tomography (PET) has considerably advanced the understanding of complex neurological disorders. PET is a powerful molecular imaging tool, which investigates the distribution and binding of radiochemicals attached to biologically relevant molecules; as such, this technique is able to give information on biochemistry and metabolism of the brain in health and disease. MRI uses high intensity magnetic fields and radiofrequency pulses to provide structural and functional information on tissues and organs in intact or diseased individuals, including the evaluation of white matter integrity, grey matter thickness and brain perfusion. The aim of this article is to review the most recent advances in neuroimaging research in common neurological disorders such as movement disorders, dementia, epilepsy, traumatic brain injury and multiple sclerosis, and to evaluate their contribution in the diagnosis and management of patients.
近年来,诸如磁共振成像(MRI)和正电子发射断层扫描(PET)等神经成像技术的应用极大地推动了对复杂神经系统疾病的认识。PET是一种强大的分子成像工具,它研究附着于生物相关分子的放射化学物质的分布和结合情况;因此,该技术能够提供有关健康和患病状态下大脑生物化学和代谢的信息。MRI利用高强度磁场和射频脉冲来提供完整或患病个体中组织和器官的结构及功能信息,包括对白质完整性、灰质厚度和脑灌注的评估。本文旨在综述运动障碍、痴呆、癫痫、创伤性脑损伤和多发性硬化等常见神经系统疾病的神经成像研究的最新进展,并评估它们在患者诊断和管理中的作用。