免疫细胞化学在惠普尔病诊断中的应用
Immunocytochemistry in the diagnosis of Whipple's disease.
作者信息
Evans D J, Ali M H
出版信息
J Clin Pathol. 1985 Apr;38(4):372-4. doi: 10.1136/jcp.38.4.372.
Abstract
In six cases of Whipple's disease the characteristic macrophages could be stained immunocytochemically using a first layer antiserum to group B streptococci. Other types of periodic acid Schiff positive macrophages were negative. The staining appears to be due to a rhamnose containing polysaccharide as shown by a blocking test. The method may be useful for confirming the diagnosis in rectal biopsy and peripheral nodes, especially if small intestinal findings are atypical.
摘要
在6例惠普尔病患者中，使用抗B组链球菌的第一层抗血清进行免疫细胞化学染色，可使特征性巨噬细胞显色。其他类型的过碘酸希夫染色阳性巨噬细胞则为阴性。阻断试验表明，这种染色似乎是由一种含鼠李糖的多糖引起的。该方法可能有助于在直肠活检和外周淋巴结中确诊，特别是当小肠检查结果不典型时。
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