Carvalho Verônica F, Andrade Priscila V C, Rodrigues Michelle F, Hirata Mario H, Hirata Rosario D C, Pannuti Claudio M, De Micheli Giorgio, Conde Marina C
Department of Periodontology, School of Dentistry, University of Sao Paulo, Sao Paulo, Brazil.
Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo, Brazil.
J Clin Periodontol. 2015 May;42(5):440-7. doi: 10.1111/jcpe.12393. Epub 2015 Apr 22.
A randomized controlled clinical trial was designed to evaluate the efficacy of the photodynamic therapy (PDT) in the treatment of residual pockets of chronic periodontitis patients.
Thirty-four patients with at least four residual periodontal pockets undergoing maintenance care were included and randomly assigned to test group (PDT, n = 18) or control group (sham procedure, n = 16). The intervention was performed at baseline, 3, 6 and 12 months. Clinical parameters such as pocket probing depth (PPD), clinical attachment level (CAL), bleeding on probing (BoP) and plaque index (PI) were measured before intervention and after 3, 6 and 12 months. Subgingival samples were obtained at baseline, and after 7 days, 3, 6 and 12 months to quantify Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Treponema denticola and Tannerella forsythia by real-time polimerase chain reaction (PCR).
All clinical variables showed significant improvement during the study, but there was no significant difference between test and control groups. The microbiological analyses showed no differences between groups at any time during the study.
Within the limits of this clinical trial and considering the laser and photosensitizer protocol used, PDT failed to demonstrate additional clinical and bacteriological benefits in residual pockets treatment.
设计一项随机对照临床试验，以评估光动力疗法（PDT）治疗慢性牙周炎患者残余牙周袋的疗效。
纳入34例至少有4个残余牙周袋且正在接受维护治疗的患者，并随机分为试验组（PDT，n = 18）或对照组（假手术，n = 16）。在基线、3个月、6个月和12个月时进行干预。在干预前以及3个月、6个月和12个月后测量临床参数，如牙周袋探诊深度（PPD）、临床附着水平（CAL）、探诊出血（BoP）和菌斑指数（PI）。在基线以及7天、3个月、6个月和12个月后获取龈下样本，通过实时聚合酶链反应（PCR）对伴放线聚集杆菌、牙龈卟啉单胞菌、具核梭杆菌和福赛坦纳菌进行定量分析。
在研究期间，所有临床变量均显示出显著改善，但试验组和对照组之间无显著差异。微生物学分析表明，在研究期间的任何时间，两组之间均无差异。
在本临床试验的范围内，并考虑所使用的激光和光敏剂方案，PDT在残余牙周袋治疗中未能显示出额外的临床和细菌学益处。
