家兔中的无症状中东呼吸综合征冠状病毒感染
Asymptomatic Middle East respiratory syndrome coronavirus infection in rabbits.
作者信息
Haagmans Bart L, van den Brand Judith M A, Provacia Lisette B, Raj V Stalin, Stittelaar Koert J, Getu Sarah, de Waal Leon, Bestebroer Theo M, van Amerongen Geert, Verjans Georges M G M, Fouchier Ron A M, Smits Saskia L, Kuiken Thijs, Osterhaus Albert D M E
机构信息
Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands
Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands.
出版信息
J Virol. 2015 Jun;89(11):6131-5. doi: 10.1128/JVI.00661-15. Epub 2015 Mar 25.
Abstract
The ability of Middle East respiratory syndrome coronavirus (MERS-CoV) to infect small animal species may be restricted given the fact that mice, ferrets, and hamsters were shown to resist MERS-CoV infection. We inoculated rabbits with MERS-CoV. Although virus was detected in the lungs, neither significant histopathological changes nor clinical symptoms were observed. Infectious virus, however, was excreted from the upper respiratory tract, indicating a potential route of MERS-CoV transmission in some animal species.
摘要
鉴于小鼠、雪貂和仓鼠已被证明能抵抗中东呼吸综合征冠状病毒（MERS-CoV）感染，该病毒感染小型动物物种的能力可能受到限制。我们用MERS-CoV接种兔子。虽然在肺部检测到病毒，但未观察到明显的组织病理学变化和临床症状。然而，感染性病毒从上呼吸道排出，这表明在某些动物物种中MERS-CoV存在潜在的传播途径。
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本文引用的文献
1
Generation of a transgenic mouse model of Middle East respiratory syndrome coronavirus infection and disease.中东呼吸综合征冠状病毒感染与疾病转基因小鼠模型的建立。
J Virol. 2015 Apr;89(7):3659-70. doi: 10.1128/JVI.03427-14. Epub 2015 Jan 14.
2
Rapid generation of a mouse model for Middle East respiratory syndrome.快速建立中东呼吸综合征小鼠模型。
Proc Natl Acad Sci U S A. 2014 Apr 1;111(13):4970-5. doi: 10.1073/pnas.1323279111. Epub 2014 Mar 5.
3
Middle East respiratory syndrome coronavirus infection in dromedary camels in Saudi Arabia.沙特阿拉伯单峰驼中中东呼吸综合征冠状病毒感染。
mBio. 2014 Feb 25;5(2):e00884-14. doi: 10.1128/mBio.00884-14.
4
Replicative Capacity of MERS Coronavirus in Livestock Cell Lines.中东呼吸综合征冠状病毒在牲畜细胞系中的复制能力
Emerg Infect Dis. 2014 Feb;20(2):276-9. doi: 10.3201/eid2002.131182.
5
Middle East respiratory syndrome coronavirus in dromedary camels: an outbreak investigation.中东呼吸综合征冠状病毒在单峰驼中的流行情况：暴发调查。
Lancet Infect Dis. 2014 Feb;14(2):140-5. doi: 10.1016/S1473-3099(13)70690-X. Epub 2013 Dec 17.
6
State of Knowledge and Data Gaps of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in Humans.中东呼吸综合征冠状病毒（MERS-CoV）在人类中的知识现状与数据缺口
PLoS Curr. 2013 Nov 12;5:ecurrents.outbreaks.0bf719e352e7478f8ad85fa30127ddb8. doi: 10.1371/currents.outbreaks.0bf719e352e7478f8ad85fa30127ddb8.
7
Adenosine deaminase acts as a natural antagonist for dipeptidyl peptidase 4-mediated entry of the Middle East respiratory syndrome coronavirus.腺苷脱氨酶可作为二肽基肽酶 4 介导的中东呼吸综合征冠状病毒进入的天然拮抗剂。
J Virol. 2014 Feb;88(3):1834-8. doi: 10.1128/JVI.02935-13. Epub 2013 Nov 20.
8
Wild-type and innate immune-deficient mice are not susceptible to the Middle East respiratory syndrome coronavirus.野生型和先天性免疫缺陷型小鼠不易感染中东呼吸综合征冠状病毒。
J Gen Virol. 2014 Feb;95(Pt 2):408-412. doi: 10.1099/vir.0.060640-0. Epub 2013 Nov 6.
9
Middle East respiratory syndrome coronavirus (MERS-CoV) causes transient lower respiratory tract infection in rhesus macaques.中东呼吸综合征冠状病毒（MERS-CoV）可导致恒河猴一过性下呼吸道感染。
Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16598-603. doi: 10.1073/pnas.1310744110. Epub 2013 Sep 23.
10
The Middle East respiratory syndrome coronavirus (MERS-CoV) does not replicate in Syrian hamsters.中东呼吸综合征冠状病毒（MERS-CoV）不能在叙利亚仓鼠中复制。
PLoS One. 2013 Jul 2;8(7):e69127. doi: 10.1371/journal.pone.0069127. Print 2013.
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