Department of Gastroenterology, General Hospital of Shenyang Military Area, Shenyang 110840, China ; Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an 710032, China.
Department of Gastroenterology, General Hospital of Shenyang Military Area, Shenyang 110840, China.
Gastroenterol Res Pract. 2015;2015:480842. doi: 10.1155/2015/480842. Epub 2015 Feb 24.
A systematic review of the literature was performed to analyze the association between portal vein thrombosis (PVT) and survival in non-liver-transplant patients with liver cirrhosis. PubMed, EMBASE, and Cochrane Library databases were searched for all relevant papers which evaluated the prognostic value of PVT in predicting the survival of liver cirrhosis. Meta-analyses were not conducted because the ways of data expression and lengths of follow-up were heterogeneous among studies. Overall, 13 papers were included. The 5-day, 6-week, and 1-year mortality were investigated in 1, 3, and 1 studies, respectively; and all of them were not significantly different between cirrhotic patient with and without PVT. By comparison, the 3-year mortality was reported in 1 study; and it was significantly increased by the presence of PVT. The overall mortality was analyzed in 5 studies; and the association with overall mortality and PVT was significant in 4 studies, but not in another one. However, as for the cirrhotic patients undergoing surgical or interventional shunts, the overall mortality was not significantly associated with the presence of PVT in 4 studies. In conclusion, the presence of PVT might be associated with the long-term mortality in non-liver-transplant patients with liver cirrhosis, but not with the short-term mortality.
系统地回顾了文献，分析了非肝移植肝硬化患者门静脉血栓形成（PVT）与生存率之间的关系。检索了 PubMed、EMBASE 和 Cochrane Library 数据库中所有评估 PVT 预测肝硬化患者生存率的预后价值的相关论文。由于研究之间的数据表达方式和随访时间长短存在异质性，因此未进行荟萃分析。总共纳入了 13 篇论文。分别在 1、3 和 1 项研究中研究了 5 天、6 周和 1 年的死亡率，并且 PVT 阳性和阴性的肝硬化患者之间的死亡率均无显著差异。相比之下，1 项研究报告了 3 年的死亡率，并且 PVT 的存在显著增加了死亡率。5 项研究分析了总体死亡率，其中 4 项研究表明与总体死亡率和 PVT 存在关联，而另一项研究则没有。然而，对于接受手术或介入分流术的肝硬化患者，4 项研究表明 PVT 的存在与总体死亡率无显著关联。总之，PVT 的存在可能与非肝移植肝硬化患者的长期死亡率相关，但与短期死亡率无关。
