• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

评价一种促进骨愈合的局部草药制剂。

Evaluation of a topical herbal agent for the promotion of bone healing.

机构信息

Institute of Chinese Medicine, 5/F, The CUHK Hong Kong Jockey Club School of Public Health Building, Prince of Wales Hospital, Shatin, New Territories, Hong Kong ; State Key Laboratory of Phytochemistry and Plant Resources in West China, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong ; Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong.

Institute of Chinese Medicine, 5/F, The CUHK Hong Kong Jockey Club School of Public Health Building, Prince of Wales Hospital, Shatin, New Territories, Hong Kong ; State Key Laboratory of Phytochemistry and Plant Resources in West China, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong.

出版信息

Evid Based Complement Alternat Med. 2015;2015:905270. doi: 10.1155/2015/905270. Epub 2015 Feb 25.

DOI:10.1155/2015/905270
PMID:25810746
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4355818/
Abstract

A topically used Chinese herbal paste, namely, CDNR, was designed to facilitate fracture healing which is usually not addressed in general hospital care. From our in vitro studies, CDNR significantly inhibited the release of nitric oxide from RAW264.7 cells by 51 to 77%. This indicated its anti-inflammatory effect. CDNR also promoted the growth of bone cells by stimulating the proliferation of UMR106 cells up to 18%. It also increased the biomechanical strength of the healing bone in a drill-hole defect rat model by 16.5% significantly. This result revealed its in vivo efficacy on facilitation of bone healing. Furthermore, the detection of the chemical markers of CDNR in the skin and muscle of the treatment area demonstrated its transdermal properties. However, CDNR did not affect the bone turnover markers in serum of the rats. With its anti-inflammatory and bone formation properties, CDNR is found effective in promoting bone healing.

摘要

一种局部应用的中草药贴剂 CDNR，旨在促进骨折愈合，这通常是综合医院护理中未涉及的。从我们的体外研究结果来看，CDNR 可显著抑制 RAW264.7 细胞中一氧化氮的释放，抑制率为 51%至 77%。这表明了它的抗炎作用。CDNR 通过刺激 UMR106 细胞的增殖，将其增殖率提高了 18%，从而促进了骨细胞的生长。它还使钻孔缺陷大鼠模型中愈合骨的生物力学强度显著增加了 16.5%。这一结果揭示了其在促进骨愈合方面的体内疗效。此外，在治疗区域的皮肤和肌肉中检测到 CDNR 的化学标志物，证明了其经皮特性。然而，CDNR 并未影响大鼠血清中的骨转换标志物。由于具有抗炎和促进骨形成的特性，CDNR 被发现可有效促进骨愈合。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff3d/4355818/a8142b992723/ECAM2015-905270.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff3d/4355818/2007c0ef06df/ECAM2015-905270.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff3d/4355818/c8e467796f00/ECAM2015-905270.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff3d/4355818/0e7de60ce987/ECAM2015-905270.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff3d/4355818/a8142b992723/ECAM2015-905270.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff3d/4355818/2007c0ef06df/ECAM2015-905270.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff3d/4355818/c8e467796f00/ECAM2015-905270.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff3d/4355818/0e7de60ce987/ECAM2015-905270.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff3d/4355818/a8142b992723/ECAM2015-905270.004.jpg

相似文献

1
Evaluation of a topical herbal agent for the promotion of bone healing.评价一种促进骨愈合的局部草药制剂。
Evid Based Complement Alternat Med. 2015;2015:905270. doi: 10.1155/2015/905270. Epub 2015 Feb 25.
2
In vitro & in vivo assessment of a herbal formula used topically for bone fracture treatment.用于骨折治疗的局部应用草药配方的体外和体内评估。
J Ethnopharmacol. 2010 Sep 15;131(2):282-9. doi: 10.1016/j.jep.2010.06.039. Epub 2010 Jun 30.
3
Integrative Approach to Facilitate Fracture Healing: Topical Chinese Herbal Paste with Oral Strontium Ranelate.促进骨折愈合的综合方法：外用中草药膏联合口服雷奈酸锶
Evid Based Complement Alternat Med. 2017;2017:9795806. doi: 10.1155/2017/9795806. Epub 2017 Dec 31.
4
Chinese topical herbal medicine gives additive effect on pharmaceutical agent on fracture healing.中药局部用药对促进骨折愈合的药物具有增效作用。
J Tradit Chin Med. 2019 Dec;39(6):853-860.
5
Synergistic interaction between Astragali Radix and Rehmanniae Radix in a Chinese herbal formula to promote diabetic wound healing.中药复方中黄芪与地黄的协同作用促进糖尿病创面愈合。
J Ethnopharmacol. 2012 May 7;141(1):250-6. doi: 10.1016/j.jep.2012.02.025. Epub 2012 Feb 17.
6
Expression of VEGF gene isoforms in a rat segmental bone defect model treated with EPCs.血管内皮生长因子异构体在 EPCs 治疗大鼠节段性骨缺损模型中的表达。
J Orthop Trauma. 2012 Dec;26(12):689-92. doi: 10.1097/BOT.0b013e318266eb7e.
7
Heartwood extract from Dalbergia sissoo promotes fracture healing and its application in ovariectomy-induced osteoporotic rats.心材提取物促进印度黄檀骨折愈合及其在去卵巢骨质疏松大鼠中的应用。
J Pharm Pharmacol. 2017 Oct;69(10):1381-1397. doi: 10.1111/jphp.12764. Epub 2017 Jun 30.
8
Impaired bone healing pattern in mice with ovariectomy-induced osteoporosis: A drill-hole defect model.去卵巢诱导骨质疏松症小鼠的骨愈合模式受损：钻孔缺陷模型。
Bone. 2011 Jun 1;48(6):1388-400. doi: 10.1016/j.bone.2011.03.720. Epub 2011 Mar 21.
9
Dried and free flowing granules of Spinacia oleracea accelerate bone regeneration and alleviate postmenopausal osteoporosis.菠菜干制且流动性良好的颗粒可加速骨再生并缓解绝经后骨质疏松症。
Menopause. 2017 Jun;24(6):686-698. doi: 10.1097/GME.0000000000000809.
10
Preclinical evaluations on the efficacy of a topical Chinese herbal formula for swelling control and pain relief.中药复方局部制剂消肿止痛作用的临床前评价。
J Ethnopharmacol. 2015 Mar 13;162:346-51. doi: 10.1016/j.jep.2014.12.073. Epub 2015 Jan 15.

引用本文的文献

1
Case Report: Therapeutic potential of traditional Korean herbal medicine Jeopgol-tang in bone regeneration: a case series of delayed union over 5 months.病例报告：韩国传统草药芍桂汤在骨再生中的治疗潜力：5个月以上延迟愈合的病例系列
Front Endocrinol (Lausanne). 2025 Jun 30;16:1595784. doi: 10.3389/fendo.2025.1595784. eCollection 2025.
2
Therapeutic Effects of Topical Traditional Chinese Medicine on Upper Extremity Fractures.中药外敷对上肢骨折的治疗作用
Int J Gen Med. 2025 Jun 9;18:2973-2988. doi: 10.2147/IJGM.S511294. eCollection 2025.
3
Antibacterial and antibiofilm potentials of root extract characterized by HPLC-ESI-Q-TOF-MS.

本文引用的文献

1
Three advantages of using traditional Chinese medicine to prevent and treat tumor.使用中医药防治肿瘤的三大优势。
J Integr Med. 2014 Jul;12(4):331-5. doi: 10.1016/S2095-4964(14)60038-8.
2
Er-Miao-San, a traditional herbal formula containing Rhizoma Atractylodis and Cortex Phellodendri inhibits inflammatory mediators in LPS-stimulated RAW264.7 macrophages through inhibition of NF-κB pathway and MAPKs activation.二妙散，一种含有苍术和黄柏的传统草药配方，通过抑制核因子κB通路和丝裂原活化蛋白激酶的激活，抑制脂多糖刺激的RAW264.7巨噬细胞中的炎症介质。
J Ethnopharmacol. 2014 Jul 3;154(3):711-8. doi: 10.1016/j.jep.2014.04.042. Epub 2014 May 6.
3
通过高效液相色谱-电喷雾电离-四极杆飞行时间质谱（HPLC-ESI-Q-TOF-MS）表征的根提取物的抗菌和抗生物膜潜力。
Saudi J Biol Sci. 2024 Apr;31(4):103962. doi: 10.1016/j.sjbs.2024.103962. Epub 2024 Feb 18.
4
Therapeutic effects of in differentiated stem cell and Matricaria chamomilla L. Oil in diabetic rabbit.未分化干细胞和母菊花油对糖尿病兔的治疗作用。
J Diabetes Metab Disord. 2020 May 11;19(1):453-460. doi: 10.1007/s40200-020-00530-3. eCollection 2020 Jun.
5
Beneficial effect of traditional Chinese medicine fumigation "Bone-healing Powder" in postoperative pain and recovery of neurological function of traumatic thoracolumbar spine fractures: A case-control study.中药熏蒸“接骨散”对创伤性胸腰椎骨折术后疼痛及神经功能恢复的有益作用：一项病例对照研究
Medicine (Baltimore). 2018 Aug;97(35):e11983. doi: 10.1097/MD.0000000000011983.
6
Integrative Approach to Facilitate Fracture Healing: Topical Chinese Herbal Paste with Oral Strontium Ranelate.促进骨折愈合的综合方法：外用中草药膏联合口服雷奈酸锶
Evid Based Complement Alternat Med. 2017;2017:9795806. doi: 10.1155/2017/9795806. Epub 2017 Dec 31.
7
Medicinal plants and bone healing.药用植物与骨愈合
Natl J Maxillofac Surg. 2017 Jan-Jun;8(1):4-11. doi: 10.4103/0975-5950.208972.
8
In Vivo Differentiation of Mesenchymal Stem Cells into Insulin Producing Cells on Electrospun Poly-L-Lactide Acid Scaffolds Coated with Matricaria chamomilla L. Oil.间充质干细胞在涂有洋甘菊油的静电纺聚左旋乳酸支架上体内分化为胰岛素分泌细胞
Cell J. 2016 Fall;18(3):310-21. doi: 10.22074/cellj.2016.4558. Epub 2016 Aug 24.
The roles of traditional Chinese medicine in gene therapy.
中药在基因治疗中的作用。
J Integr Med. 2014 Mar;12(2):67-75. doi: 10.1016/S2095-4964(14)60019-4.
4
Organic nitrate maintains bone marrow blood perfusion in ovariectomized female rats: a dynamic, contrast-enhanced magnetic resonance imaging (MRI) study.有机硝酸盐维持去卵巢雌性大鼠骨髓血液灌注：一项动态对比增强磁共振成像（MRI）研究。
Pharmaceutics. 2012 Dec 21;5(1):23-35. doi: 10.3390/pharmaceutics5010023.
5
Extract of buckwheat sprouts scavenges oxidation and inhibits pro-inflammatory mediators in lipopolysaccharide-stimulated macrophages (RAW264.7).荞麦芽提取物清除氧化应激并抑制脂多糖刺激的巨噬细胞（RAW264.7）中的促炎介质。
J Integr Med. 2013 Jul;11(4):246-52. doi: 10.3736/jintegrmed2013036.
6
Antidiarrheal properties of different extracts of Chinese herbal medicine formula Bao-Xie-Ning.中药复方葆泄宁不同提取物的止泻作用。
J Integr Med. 2013 Mar;11(2):125-34. doi: 10.3736/jintegrmed2013019.
7
Healing patterns of critical size bony defects in rats after grafting with bone substitutes soaked in recombinant human bone morphogenetic protein-2: histological and histometric evaluation.用重组人骨形态发生蛋白-2浸泡的骨替代物移植后大鼠临界尺寸骨缺损的愈合模式：组织学和组织计量学评估
Br J Oral Maxillofac Surg. 2013 Sep;51(6):545-9. doi: 10.1016/j.bjoms.2012.08.005. Epub 2012 Aug 31.
8
Adherence to therapeutic and diagnostic recommendations in patients with femur fracture and at risk of re-fracture or death: results of an analysis of administrative databases.股骨骨折且有再次骨折或死亡风险患者对治疗和诊断建议的依从性：行政数据库分析结果
Reumatismo. 2012 Mar 16;64(1):18-26. doi: 10.4081/reumatismo.2012.18.
9
Anticancer effects of imperatorin isolated from Angelica dahurica: induction of apoptosis in HepG2 cells through both death-receptor- and mitochondria-mediated pathways.白芷中分离得到的欧前胡素的抗癌作用：通过死亡受体和线粒体介导的途径诱导 HepG2 细胞凋亡。
Chemotherapy. 2011;57(6):449-59. doi: 10.1159/000331641. Epub 2012 Jan 7.
10
Postcontusion polyphenol treatment alters inflammation and muscle regeneration.挫伤后多酚处理改变炎症和肌肉再生。
Med Sci Sports Exerc. 2012 May;44(5):872-80. doi: 10.1249/MSS.0b013e31823dbff3.