Comparative Genomics Centre, Molecular Sciences Bldg 21, James Cook University, Townsville, Queensland 4811 Australia.
Immunolology Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052 Australia ; Department of Medical Biology, The University of Melbourne, Parkville, Victoria 3010 Australia.
Genome Med. 2015 Mar 25;7(1):29. doi: 10.1186/s13073-015-0156-0. eCollection 2015.
Recent twin studies highlight the astonishing impact of non-heritable contributions to our immune health and wellbeing. Immunologists, long familiar with heterogeneity generated from within cells, must now grapple with heterogeneity between and within individuals which is present to an extraordinary degree. The capacity to interpret and find patterns in the face of such immune system diversity may be limited when sampling is restricted to blood, necessitating the development of new approaches.
最近的双胞胎研究强调了非遗传性因素对我们的免疫健康和幸福的惊人影响。长期以来，免疫学家对细胞内产生的异质性很熟悉，但现在必须应对个体之间和个体内部存在的高度异质性。当采样仅限于血液时，解释和发现这种免疫系统多样性中的模式的能力可能会受到限制，因此需要开发新的方法。
