Elshweikh Samah A, Elkhouly Radwa M, Shaalan Mohamed M, Shorbagy Safinaz H
Egypt J Immunol. 2014;21(2):49-59.
Renal involvement is common in systemic lupus erythematosus (SLE). Anti-C1q antibodies are associated with SLE nephritis. This study attempted to correlate anti-C1q levels to different types of lupus nephritis (LN). Anti-C1q antibodies were assessed in two groups (15 subjects each) of SLE patients with and without LN. Ten apparently healthy volunteers served as controls. The sensitivity of anti C1q for diagnosis of lupus nephritis among SLE patients was 100.00% and the specificity reached 90.00%. The positive and negative predictive values for renal activity were 83.3% and 100.00%, with a predictive accuracy of 98.00%. The level of anti C1q was highest in patients with class IV lupus nephritis. We conclude that negative anti- C1q test results would exclude active nephritis in SLE. Our data support the hypothesis that anti-C1q antibodies may have pathogenic role in lupus nephritis.
肾脏受累在系统性红斑狼疮（SLE）中很常见。抗C1q抗体与狼疮性肾炎相关。本研究试图将抗C1q水平与不同类型的狼疮性肾炎（LN）相关联。在两组（每组15名受试者）有和无LN的SLE患者中评估抗C1q抗体。十名明显健康的志愿者作为对照。抗C1q对SLE患者狼疮性肾炎诊断的敏感性为100.00%，特异性达到90.00%。肾脏活动的阳性和阴性预测值分别为83.3%和100.00%，预测准确率为98.00%。IV类狼疮性肾炎患者的抗C1q水平最高。我们得出结论，抗C1q检测结果为阴性可排除SLE中的活动性肾炎。我们的数据支持抗C1q抗体可能在狼疮性肾炎中具有致病作用这一假说。
